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Yeah. So maybe we could start with that background – what got you into secondary metabolism, besides being forced to … like to look at, historically, for these pathways, they’ve got really high GC content, which means their base usage is … ALISON: Okay. And so maybe just to back up, because you started talking about the microbes that produce these …

… to get a new one out every two weeks. This time, we’ve got a great interview with Ben Shen, from the Scripps … is infectious. DAN: I’ll say up front that JGI recently started collaborating with Ben and his group to work on … stand for…?  BEN: Antibody Drug Conjugates.  ALISON: Okay, gotcha.  BEN: Yeah. To “conjugate” means to link antibody …

Science Program at JGI, and also my boss, Nigel Mouncey. I got him on to talk about JGI’s vision for secondary … but no worries, she’ll back next time! We’ve already got lots of great talks recorded and on the way – I’m going … we’d look at 10,000, 15,000, 20,000 mutants a week. We started doing a whole bunch of strain engineering efforts. …

… her to a successfully funded JGI CSP project. And we also got to talk about work at her University on graduate student … natural products? BETSY PARKINSON: Sure. Definitely. So, I got my PhD with Paul Hergenrother at the University of … I'd love to. So coming from a synthetic background, when I started doing a lot of this natural product production …

… that know me call me Kate. Dan Udwary: Great. So we’ve got Kate here today, and we wanted to talk to her about a … first question. Kate, can you tell me the story of how you got into secondary metabolites? Kate Duncan: So I always … And I tell all my students this now, but when I started my PhD, I’d never poured a Petri dish. I didn’t know …

… talk about a new JGI paper that’s just come out where I got the chance to do genome mining on more than 50,000 … international scientists who also do genome mining. We’ve got a great, fun bunch of little shows lined up, and I’m … start by panning for the gold in the streams. And when you started finding– you would go up and down the stream, and …

… if you see the bacteria dying, then you know you’ve got an antibiotic that might be useful. And so that was … to keep this drug discovery train moving, drug companies started working with some techniques referred to as … easily just by combining A and B and B and C, and you’ve got a new molecule, right? And so if you have 1000 A’s and …

… do and how they evolve. ALISON TAKEMURA: So Nadine, what got you interested in studying natural products? NADINE … ZIEMERT: I needed a job during college or university, and I got this great job as a student assistant in the lab of Elke … with nature products from cyanobacteria. So that’s how I started. I love the lab, I love the topic, and I think what …

… this? JACLYN WINTER: I’ll kind of go back to where it all started. I think for me, natural products– I became … what other organisms are there. And so the chemistry has got to be new, or at least we hope. This is what we’re using … genomes. JACLYN WINTER: Wow. DAN UDWARY: And I think we’ve got another 200,000 or 300,000 bacteria to go in before we …

Status Reports … We look forward to getting your project started! …

… graduate student then a postdoc and then a job.” Instead I got interested pretty early on regarding cancer medicines … and realizing that wasn’t for me and eventually, I got to chemistry. And as I was doing my chemistry work I … where I wanted you to go with this.  MARCY: Yes. And so we started out in the universe of natural product isolation. …