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The mission of the Joint Genome Institute is to serve the … … For sequencing projects, once work is under way, raw sequence data is released to NCBI’s Sequence Read Archive on a regular basis, in accordance with …

… … DAN UDWARY: You’re listening to the Department of Energy Joint Genome … there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And I think … it would work, but we actually found fosmids. And we sequenced the whole fosmid at the time with Sanger …

… you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … groups are working on this area on the ribosomal peptides. Types of things you can do: By changing these properties, … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

See below for a list of Frequently Asked Questions about our proposal … on the call link to see specific details including project types supported, sample/capacity limits, and instructions.  … for advice!      … The deliverables can range from raw sequence data to well-annotated assembled genomes to …

… at JGI start with sequencing, but where else did those sequences go? Like, what are the other scientific tools we … that describe the work. In general. Scientific merit and why it’s important. The DOE mission is one of these … et cetera, depending on the product. We push different types of data sets to GenBank and CPI. MENAKA WILHELM: Is …

The JGI has a strong interest in seeing that the data produced by … (see Auspice Statement below) for the generation of sequence or metabolomic data, DNA synthesized, and any other … of sequence, metabolomics, and functional genomics data types as well as in advanced assembly and engineering …

… then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against … as far as mixed halogenation, di-halogenation. And types of processes that one could imagine biocatalysts being …

… about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean … genes that are signatures for the presence of a specific type of biosynthetic gene cluster. And antiSMASH has a …

The Joint Genome Institute's DNA Synthesis Platform capabilities support researchers exploring how to convert sequence into functional assessments. This is done by … design tool  … BOOST provides a suite of tools to automate sequence design for assembly by Gibson, Yeast recombination …

… at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways … MARC: This isn’t true of all of them, but for certain types, they’re extremely repetitive. And what that means …

… in some of the gamma-butyrolactone (GBL) and butenolide type hormones. And so, these hormones actually oftentimes … The genes are pretty much 100% identical. We don't know why one is expressed over the other. As far as whether we're … usually serve as dimers, and then they will bind to certain sequences of DNA. And when they bind to those certain …

… bacteria that work against protistsproduce, algae and other types of settlers.  DAN: Yeah you would think. Anything that … does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to …