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… so they’re secondary metabolite peptides. And there are two ways that nature does this. The more well-known … you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… welcome back to a new session of Natural Prodcast. I’ve got two things I wanted to tell you about in this introduction. … And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, …

… Below is a brief description of the process needed to prepare and ship samples for sequencing by the JGI.  Additionally it includes … sample QC requirements and protocols Obtaining DNA and RNA of suitable quantity and quality has been the rate-limiting step for many projects at the JGI. The quality of the starting …

… “Adopt a Genome” is an informal program for faculty to “claim” the JGI’s unpublished … work with undergraduates in the analysis and publication of the claimed genome sequences. This opportunity, provided by the Joint Genome … necessary to extract meaningful biological insights from sequence data, employing IMG data and tools for comparative …

… Every approved proposal starts with a User Agreement — before any work can begin, including the submission of samples for sequencing, or the submission of sequencing data for synthesis. This agreement, required … After your proposal is approved, the Contracts Officer will send required paperwork to your …

… Mass spectrometry based metabolomics Below is a table of standard product offerings, including a description of … to completion of standard analysis.  Raw data is provided for all sequencing products below. In addition, JGI will submit raw sequence data to  SRA at NCBI once the standard analysis is …

… least, talk to us, first about my definitions of things and why I am wrong, and also talk about some of the great … is what. This is not new. It actually was first proposed by two authors called Firn and Jones. I’m sure that people … to approach it is more related to what JGI does, which is sequence genomes. And we just published last year in the …

… The mission of the Joint Genome Institute is to serve the scientific … discovery at the DOE Office of Science through high performance computing (HPC) and data analysis.  The DOE Systems … ) integrates systems biology data and tools to help predict biological function.   To jointly support these missions, …

… intriguing. The squid – the Hawaiian bobtail squid has two organs that solely house– whose sole function is to … does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to …

… culture-disconnected. Like we’ll take some soil samples and sequence all the bugs out of that or whatever. And so I was … resources, but they don’t necessarily have the support network, the equipment, the facilities to really apply the … methicillin-resistant Staphylococcus aureus . Can you share why finding treatments for these microbes is so important? …

…   The Joint Genome Institute's Biodesign Platform capabilities support researchers exploring how to convert sequence into functional assessments. This is done by … automations for DNA design, assembly and analysis Overview of biodesign products The JGI Biodesign platform enables …

… more than 50,000 genomes that we derived from meta-genome sequences. As always, you’ll find transcripts and show notes … for us– what organisms people use for genome mining, why it’s called genome mining, how the biosynthetic gene … lots of stuff. On average, we had something– I think we had two biosynthetic clusters per MAG, which is pretty good …