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… there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And I think … gene classes I could start on. So… but you started with two genomes, right? DAN UDWARY: Right. NADINE ZIEMERT: And … it would work, but we actually found fosmids. And we sequenced the whole fosmid at the time with Sanger …

… least, talk to us, first about my definitions of things and why I am wrong, and also talk about some of the great … is what. This is not new. It actually was first proposed by two authors called Firn and Jones. I’m sure that people … to approach it is more related to what JGI does, which is sequence genomes. And we just published last year in the …

… (see Auspice Statement below) for the generation of sequence or metabolomic data, DNA synthesized, and any other … is done in a timely fashion. The publications resulting from such efforts should specify the collaborative nature of … annotation, comparative analysis, and interpretation of sequence, metabolomics, and functional genomics data types …

I’m interested in the world of natural products is also twofold but for different reasons to learn about how nature … enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh …

… culture-disconnected. Like we’ll take some soil samples and sequence all the bugs out of that or whatever. And so I was … resources, but they don’t necessarily have the support network, the equipment, the facilities to really apply the … methicillin-resistant Staphylococcus aureus . Can you share why finding treatments for these microbes is so important? …

… about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean … better to do it together, to join forces instead of to make two competing tools. If we had known about your tool, Dan, …

… capabilities support researchers exploring how to convert sequence into functional assessments. This is done by … develops data science tools for workflow management and novel automations for DNA design, assembly and analysis … platform enables users to validate hypotheses generated from mining genomic data by designing and assembling …

… at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways … sending signals. But really unpacking that complicated network of chemistry and communication is what I’m really …

… capabilities and products . A minimum request of 1 Tb of sequence data is required to qualify for BERSS. For DNA … with grants funded by DOE-BER requiring support from the JGI may  submit proposals here . Investigators …  should fill out this form . Please allow a minimum of  two weeks for your request to be processed. Investigators …

Laboratory. Being a User Facility means that scientists from all over the world bring us big problems related to … stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain … studied microbial ecology. I studied Vibrio species in the ocean, so heterotrophic bacteria. Now, we didn’t get into …

… welcome back to a new session of Natural Prodcast. I’ve got two things I wanted to tell you about in this introduction. … And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, …

… intriguing. The squid – the Hawaiian bobtail squid has two organs that solely house– whose sole function is to … does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to …