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… research that drives sustainable solutions in energy, agriculture and ecosystem management. … which are critical for advancing sustainable solutions in agriculture, energy and ecosystem management. The program … using single cell approaches. This includes linking strain-level genetic variation to ecological niche …

… industry. When Director Nigel Mouncey joined the JGI in 2017, he brought with him 20 years of industry experience — … dominance by integrating supercomputers, datasets and AI agents to solve key national challenges. The Genesis Mission … Office and Intellectual Property Office to execute agreements. Learn more about partnering with the DOE's …

… are subject to a  two-year embargo starting at construct or strain delivery.  Detailed sequence information and constructs are made publicly … outside repositories until the earliest of three points:  (1) publication of the data (including, but not limited to, …

… transcriptomic, proteomic, phenotypic, metabolomic, imaging, sensor, and other data produced at scales amenable to … To meet these needs, the JGI deploys state-of-the-art sequencers and platforms dedicated to synthesis, single-cell … same time, the team is expanding current capabilities in strain engineering and functional assays and supporting new …

… ranked proposal list, along with a recommendation from management at JGI and the other participating facilities, is … DOE for final approval.  Following DOE approval, project managers negotiate project specifics with PIs (including JGI … For sequencing projects, once work is under way, raw sequence data is released to NCBI’s Sequence Read Archive on …

… nature does this with such elegance And also to take advantage of the biological properties that these molecules have … enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh …

… and eukaryotic microbes and viruses in environmental sequence data. We use multi-omics (metagenomics, metatranscriptomics, single cell genomics and … and machine learning to identify new divergent lineages and expand the Tree of Life. We then investigate the … Cataloging Earth's microbial lineages through advanced genomic techniques and computational …

… more than 50,000 genomes that we derived from meta-genome sequences. As always, you’ll find transcripts and show notes … what you’re talking about. ALISON TAKEMURA: A long time ago. DAN UDWARY: But when I picture these, I picture myself … for us– what organisms people use for genome mining, why it’s called genome mining, how the biosynthetic gene …

… of their synthases so that we can start to use the DNA sequence to predict or just understand better the language … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. … what we’re trying to do right now is develop the chassis strains that then we can port things into as well. DAN: Give …

… is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … And these organisms are pretty gnarly. We have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a …

… The genes are pretty much 100% identical. We don't know why one is expressed over the other. As far as whether we're … usually serve as dimers, and then they will bind to certain sequences of DNA. And when they bind to those certain … ring systems. JACKIE: Why? Is it just because of ring strain or is it-- I guess, what's the efficiency between …

… that we recorded this conversation about 10 months ago. I was pretty green at the time and had some really … least, talk to us, first about my definitions of things and why I am wrong, and also talk about some of the great … to approach it is more related to what JGI does, which is sequence genomes. And we just published last year in the …