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… is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … bit more into fungi and learning the differences of all the genetic differences and then expanded on on that knowledge … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a …

The Sequencing Technologies Group applies cutting edge molecular capabilities and state-of-the-art next-generation sequencing to enable biological discovery by the …

After I got my undergraduate degree, which was in general biology, I joined the Peace Corps. And when I was … out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   … it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk …

… what we’re calling a Primer. We wanted to try and give a general audience some of the basics of natural products … stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain … I’m definitely seeing why this is such an important area to study. Okay, what’s your third story?  DAN: The third story …

… of their synthases so that we can start to use the DNA sequence to predict or just understand better the language … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. … supernatant and send that to back to JGI and have them do untargeted metabolomics, which we can then using some tricks …

Program supports a wide range of projects, from single-gene synthesis to the synthesis of entire chromosomes, … Program aims to generate large datasets to explore sequence-function relationships, advancing the discovery of … missions. Using bioinformatics tools and genome portals, we study lignocellulose decomposition, CO2 fixation, redox …

… does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … products is that we don’t know what all the biosynthetic gene clusters look like.  DAN: For sure.  MARCY: We have so … with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to …

… that produces those. So it’s not a hard and fast rule, but, generally, animals do not have secondary metabolism that we … DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have …

… my undergraduate in microbiology and then PhD in microbial genetics in the UK. And came across to the US for a couple … And these were not in natural products, these were in studying regulatory mechanisms of, first, E. coli and then … to some people more about down the road. Email Nigel! He’ll sequence whatever you want!  [LAUGHTER]  NIGEL MOUNCEY: We …

… focuses on the utility of single-cell methods to access genetic material of uncultivated taxa of interest. One such effort is targeted at environmental cells that are from candidate … is also reflected in the strongly biased representation of sequenced genomes in the public domain, the bulk of which …

… as a new type of medicine that will open up a new year for targeted anti cancer drug discovery. DAN: Yeah, great. Are … the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very …

… and strategic objectives of the JGI. The SAC serves as the Institute's key external advisory panel and advocate of the … of the committee is to take the input from the CSP Proposal Study Panel on prioritization of CSP projects and, with … and Environmental Research (BER) program, set the final sequence allocation for this program. …