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… in doing so enabled the JGI to be the first to publish the sequence analysis of the target chromosomes 5, 16, and 19, …

… more than 50,000 genomes that we derived from meta-genome sequences. As always, you’ll find transcripts and show notes … bunch of little shows lined up, and I’m really looking forward to getting them out to you all. But for now, here is … for us– what organisms people use for genome mining, why it’s called genome mining, how the biosynthetic gene …

… stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain … more about some of the background and sort of the reasons why we want to do this. And also to provide a little more … of the fun things that I hope that I can express today is why secondary metabolism is interesting and why it is that …

… you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a … the ocean are doing. And specifically, they’re aimed outwards at the behavior of other animals. And so they are …

… Our research focuses on the assembly of metagenomic sequence data into microbial genomes, which is of … Profile HMM search across all IMG metagenomes, capturing sequence diversity for proteins of interest. … better understanding of complex ecosystems within hard to sequence and assemble samples, such as those from soil and …

… aiming for the first Thursday of the month moving forward. So, that’s the schedule, I’m committing to it, and you … And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, …

… at JGI and the other participating facilities, is then forwarded to DOE for final approval.  Following DOE approval, … For sequencing projects, once work is under way, raw sequence data is released to NCBI’s Sequence Read Archive on a regular basis, in accordance with …

… at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways … have against pathogens from the clinic. At that point, isolates get shipped to us in Wisconsin, and we try and use …

… out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   … it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk … this and that. They’re doing all this 16S and I said, “Why don’t you just include the ITS too? It’s so easy to add …

… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … not know what to do. We did not know how to culture marine isolates from the ocean. We didn’t know whether to study … forward to seeing the data when it finally gets off the sequencers. The pandemic has obviously slowed JGI down a …

… then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against … to correlate chemical to genes. We’re hoping we can move forward and we’re challenging our colleagues at Monterey Bay, …

… (see Auspice Statement below) for the generation of sequence or metabolomic data, DNA synthesized, and any other … impact of user research. The crucial elements are proposal Award DOI(s), JGI’s ROR ID number, DOE contract numbers … in any external publications, and include proposal Award DOIs following the guidelines below. …