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… culture-disconnected. Like we’ll take some soil samples and sequence all the bugs out of that or whatever. And so I was … methicillin-resistant Staphylococcus aureus . Can you share why finding treatments for these microbes is so important? … in bacteria as well. Yeah. DAN UDWARY: Yeah. Yeah, common root.  ALISON TAKEMURA: And so is that how your ethnobotany …

MARCY: And that they’re laid – unlike octopus which tend to their eggs and so they don’t get biofilm. Squid just deposit … does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to …

… right from the beginning, I always wanted to be true to my roots, and always work with marine systems because that’s … then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against …

… analyzing primary and secondary metabolites helps uncover their roles in processes such as nutrient cycling, … novel insights into the impact of microbial symbionts and their hosts on ecosystems.   Environmental molecular …

… about sponges, can you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very … of scientists over the years that have essentially devoted their life to collect microorganisms all over the world for …

… pipelines.  You will receive automated emails as raw sequence data becomes available, and as analysis is …

… more than 50,000 genomes that we derived from meta-genome sequences. As always, you’ll find transcripts and show notes … in as medicines, but also things that are important in their own environments. Like, bacteria make antibiotics in … for us– what organisms people use for genome mining, why it’s called genome mining, how the biosynthetic gene …

… incredibly interested in what fungi could do and what their natural products could do to us. So I’d say my initial … out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   … it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk …

… of young researchers, so it’s important to me to tell their stories too. If you have one of those stories, or want … at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways …

Uncovering associations between plant roots and fungi that can help or harm plant host health. The … from natural Arabidopsis populations around Europe. The JGI sequenced and annotated 41 fungal isolates from the … pectin. The results therefore predicted that these root-colonizing fungi must be kept in check by the host and other …