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… focuses on the exploration of secondary metabolites across bacteria, fungi, algae and plants. These molecules, which … reservoir of secondary metabolites produced by bacteria, fungi, algae and plants. These compounds are key … computational analyses of BGC size and complexity, BGC sequence composition, metabolic similarity & compatibility, …

… work like ActDES, which is a curated database of actinobacteria for evolutionary studies, and hopefully we can … least, talk to us, first about my definitions of things and why I am wrong, and also talk about some of the great … to approach it is more related to what JGI does, which is sequence genomes. And we just published last year in the …

… biology classes in undergrad, but my PhD was an actinobacteria. And I tell all my students this now, but when I … Duncan: Yeah. I love actinomycetes. Dan Udwary: Tell us why. I mean, I know, but I think– Alison Takemura: I want to … of almost finished characterizing them. We’ve got genome sequences, which are just incredible. We’ve looked at the …

… more than 50,000 genomes that we derived from meta-genome sequences. As always, you’ll find transcripts and show notes … find, things that are of interest. And usually, in terms of bacteria and secondary metabolism, those things that we want … for us– what organisms people use for genome mining, why it’s called genome mining, how the biosynthetic gene …

… chemical compounds that you find in plants, fungi and bacteria, basically all living things. When your crazy Aunt … stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain … more about some of the background and sort of the reasons why we want to do this. And also to provide a little more …

… in their natural environments. This work encompasses bacteria, archaea, and micro-eukaryoes, along with their … comprising the largest public collection of plasmid sequences identified from genomes, SAGs, MAGs, metagenomes …

… the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very … origin is around 30,000 from fungal, and a 40,000 from bacteria. Okay? And among the 40,000 from bacteria, there’s …

… been dominated for … well, as long as I can remember, by bacterial research.  So it was great to hear her passion and … out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   … it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk …

… about several different pieces of her work, including bacterial quorum sensing and its effects on regulation of … The genes are pretty much 100% identical. We don't know why one is expressed over the other. As far as whether we're … usually serve as dimers, and then they will bind to certain sequences of DNA. And when they bind to those certain …

… is focused on the discovery and characterization of novel bacterial, archaeal and eukaryotic microbes and viruses in environmental sequence data. We use multi-omics (metagenomics, … danicum gen. nov., sp. nov. in the ubiquitous bacterial phylum Patescibacteriota phyl. nov .”  ISME …

… colleagues. Aaron is doing some cool stuff with cool bacteria that I’m fascinated to learn more about. He works … of their synthases so that we can start to use the DNA sequence to predict or just understand better the language … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. …