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… more than 50,000 genomes that we derived from meta-genome sequences. As always, you’ll find transcripts and show notes … for us– what organisms people use for genome mining, why it’s called genome mining, how the biosynthetic gene … machine learning really would help distinguish and predict novel gene clusters. DAN UDWARY: Yeah, it certainly could. …

… Molecular Cell 2019) and massive reconstruction of genomes from uncultivated microbes (Nature 2019). Other projects in … and comparative analysis of thousands of archaeal and bacterial type strains ( GEBA-type strains project ), the … of the functional dark matter as well as the development of novel methods to enable large-scale comparative analysis, …

… is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a … seems to be a new structure, and the microorganisms are novel. I mean, we have Streptomyces , but they’re new …

… to kill cells. So it’s really remarkable in terms of a novel mechanism, how a small molecule can kill. So that … the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very …

… does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … We find chemistry that’s known, or sometimes novel, but often known, and yet the clusters don’t look the … with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to …

… been dominated for … well, as long as I can remember, by bacterial research.  So it was great to hear her passion and … out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   … it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk …

… least, talk to us, first about my definitions of things and why I am wrong, and also talk about some of the great … BARONA-GOMEZ: Yeah, so any metabolite, produced by bacterial or fungal metabolism by microbes, will have a … to approach it is more related to what JGI does, which is sequence genomes. And we just published last year in the …

… Our homepage video includes external footage from: University of Delaware; Laura.Selbmann©PNRA. All the … isolated are preserved in the Culture Collection of Fungi from Extreme Environment, the Italian National …

… of their synthases so that we can start to use the DNA sequence to predict or just understand better the language … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. … to identify what’s being made. In some cases it might be novel, in some cases it might be– might be a known structure …

… And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … in order to put them together to build pathways, to make novel compounds, or to find analogs. And that was Warp …

… use successfully, hopefully, in the future even more so as novel therapies. And that’s how I got on that path of … culture-disconnected. Like we’ll take some soil samples and sequence all the bugs out of that or whatever. And so I was … methicillin-resistant Staphylococcus aureus . Can you share why finding treatments for these microbes is so important? …

… genomics with metabolomics fuels the discovery  of novel metabolites, genes, and proteins. It also enables … exploration of energy and nutrient exchange, as well as microbial and plant responses to environmental changes. With … mass spectrometry-based methods to analyze metabolites from a wide range of biological and environmental samples — …