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… more than 50,000 genomes that we derived from meta-genome sequences. As always, you’ll find transcripts and show notes … for us– what organisms people use for genome mining, why it’s called genome mining, how the biosynthetic gene … of the IMG data portal , which is a larger portal for microbial genomics. IMG stands for Integrated Microbial …

… and other omics technologies.  The exponential growth of DNA sequencing data, coupled with recent computational … advances in management, processing and visualization of “big data,” and artificial Intelligent/machine learning … breakthrough discoveries and catalyzing a major transition of biology into data science.  Research in the Kyrpides …

…   The U.S. Department of Energy (DOE) Joint Genome Institute (JGI) is a national … at Lawrence Berkeley National Laboratory. The JGI consists of 225 researchers and support staff in the Integrative … from plants, fungi, algae, non-medical microbes, microbial communities, and other relevant organisms. We …

… group aims at improving our collective understanding of ecological and evolutionary parameters driving virus:host dynamics in environmental microbial communities. This involves both experimental and computational exploration of uncultivated viral diversity, characterization of molecular mechanisms involved …

… Research in the Woyke laboratory focuses on the utility of single-cell methods to access genetic material of uncultivated taxa of interest. One such effort is … in 1985, which highlights our skewed understanding of microbial metabolism towards a minority of cultivated …

… Secondary Metabolites Program focuses on the exploration of secondary metabolites across bacteria, fungi, algae and … advantages to the organisms producing them, and are often involved in defense, nutrient acquisition and … program aims to tap into the largely unexplored biochemical diversity within secondary metabolites, expanding their …

… The JGI’s Metabolomics Program works to uncover the roles of small molecules in biological systems, linking them with genomic data to enhance our understanding of genome science, organisms, and ecosystems at the … exploration of energy and nutrient exchange, as well as microbial and plant responses to environmental changes. With …

… tell us about this squid-microbe relationship. Or is it a microbial community with microbial community relationship?  … does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to …

… the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very … genomic revolution, to me, as a natural part chemist for microbial natural product, is that I love microbial natural …

… there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And I think … it would work, but we actually found fosmids. And we sequenced the whole fosmid at the time with Sanger … see. So it doesn’t seem to be a correlation between biodiversity in taxa and biodiversity in secondary metabolites. …

… The mission of the Joint Genome Institute is to serve the scientific … relevant bioenergy and environmental problems.  The mission of the National Energy Research Scientific Computing Center … ( NERSC ) is to accelerate scientific discovery at the DOE Office of Science through high performance computing (HPC) …

… enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh … made it onto our list is because we wanted to have diversity. And so we wanted a profile across that protein …