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… research.  These efforts include exploration of the global diversity of alternative genetic codes (Science 2014), … A global metagenomic map of urban microbiomes and antimicrobial resistance. Cell . 184(13):3376-3393 Almeida A, et … al. (2017) Protein structure determination using metagenome sequence data. Science   355(6322):294-298 Paez-Espino D. et …

Secondary Metabolites Program focuses on the exploration of secondary metabolites across bacteria, fungi, algae and … program aims to tap into the largely unexplored biochemical diversity within secondary metabolites, expanding their … computational analyses of BGC size and complexity, BGC sequence composition, metabolic similarity & compatibility, …

… in 1985, which highlights our skewed understanding of microbial metabolism towards a minority of cultivated … still persists to date. Research Team    … Phylogenetic diversity estimates show that the gap between cultivated and … is also reflected in the strongly biased representation of sequenced genomes in the public domain, the bulk of which …

… on genomic science projects that address sustainable biofuel and bioproducts production, leveraging systems-based … to unravel functional capabilities of plants, microbes and microbial communities, global carbon and nutrient cycling, … emphasis that are listed in the call and leverage the diversity of JGI technical and analytical capabilities. All …

… the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very … genomic revolution, to me, as a natural part chemist for microbial natural product, is that I love microbial natural …

… group aims at improving our collective understanding of ecological and evolutionary parameters driving virus:host dynamics in environmental microbial communities. This involves both experimental and computational exploration of uncultivated viral diversity, characterization of molecular mechanisms involved …

… tell us about this squid-microbe relationship. Or is it a microbial community with microbial community relationship?  … does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to …

…   The U.S. Department of Energy (DOE) Joint Genome Institute (JGI) is a national … at Lawrence Berkeley National Laboratory. The JGI consists of around 280 researchers and support staff in the …

… there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And I think … it would work, but we actually found fosmids. And we sequenced the whole fosmid at the time with Sanger … see. So it doesn’t seem to be a correlation between biodiversity in taxa and biodiversity in secondary metabolites. …

Metagenomic datasets could help map out microbial diversity hotspots Over the past few decades, advancements … genomic biodiversity. Using publicly available genome sequence data generated over the past three decades, their …

The JGI’s Metabolomics Program works to uncover the roles of small molecules in biological systems, linking them with … exploration of energy and nutrient exchange, as well as microbial and plant responses to environmental changes. With … systems can provide novel insights into the impact of microbial symbionts and their hosts on ecosystems.   …

Plants are complex organisms that harbor a fantastic diversity of cell types and associated organisms, including fungal and bacterial symbionts, detrimental microbial pathogens, and associated viruses that all …