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… systems. No one was, at that time, really working with microbes from the ocean. So I felt there was a wonderful … then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against …

And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … them on a regular basis. So they are full of terrestrial microbes. So they’re open ecosystems. They’re not sealed off …

… least, talk to us, first about my definitions of things and why I am wrong, and also talk about some of the great … At the end of the day, all the content produced by microbes the result of millions of years of evolution. And … to approach it is more related to what JGI does, which is sequence genomes. And we just published last year in the …

As waters warm due to climate change, corals are in mortal … When warm waters stress corals, it might be their microbes, including their photosynthetic partner, that help …

The Metagenome Program uses advanced sequencing technologies to decode the genomes of microbes in their natural environments. This work … comprising the largest public collection of plasmid sequences identified from genomes, SAGs, MAGs, metagenomes …

… of novel bacterial, archaeal and eukaryotic microbes and viruses in environmental sequence data. We use multi-omics (metagenomics, …

…   The U.S. Department of Energy (DOE) Joint Genome Institute (JGI) is a national user facility located at … JGI consists of around 280 researchers and support staff in the Integrative Genomics Building in Berkeley, …

… we really recognize, right?  ALISON: And I tend to think of microbes as being able to secrete a lot more things than … DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have …

… product reports on the evolution of genome mining and microbes with Mohammad Alanjary and Tilmann Weber to be a … there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And I think … it would work, but we actually found fosmids. And we sequenced the whole fosmid at the time with Sanger …

The genes are pretty much 100% identical. We don't know why one is expressed over the other. As far as whether we're … usually serve as dimers, and then they will bind to certain sequences of DNA. And when they bind to those certain … fun that we've started that is a different subject is from microbes to medicine labs. So this is-- we've been working …

… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … you think about the fact that, when plants and animals and microbes evolve, they evolve to make molecules that improve … forward to seeing the data when it finally gets off the sequencers. The pandemic has obviously slowed JGI down a …

The mission of the Joint Genome Institute is to serve the scientific community as … … For sequencing projects, once work is under way, raw sequence data is released to NCBI’s Sequence Read Archive on a regular basis, in accordance with …