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… and eukaryotic microbes and viruses in environmental sequence data. We use multi-omics (metagenomics, … tool for generating synthetic sequencing data from genomic sequences … A predictive tool for microbial symbionts in environmental sequence data, including microbial phenotype along the …

… people all over the word who have a common interest, united by natural products, DAN: You guys have put together a … the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very …

… stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain … search away! If you like these primer episodes, let me know by emailing us to [email protected], or on twitter @JGI or … more about some of the background and sort of the reasons why we want to do this. And also to provide a little more …

… Science Program , or CSP, which is the main mechanism by which users work with our facility to do science. Since I … at JGI start with sequencing, but where else did those sequences go? Like, what are the other scientific tools we … that describe the work. In general. Scientific merit and why it’s important. The DOE mission is one of these …

… datasets, particularly for uncultivated microorganisms, by sequencing large populations of bacteria and archaea in … lineages that are important for bioeconomy applications. By expanding our knowledge of microbial functions and … resequencing, RNA sequencing and epigenomics. Expansion of sequence space:  The JGI generates reference genomes from …

… capabilities and products . A minimum request of 1 Tb of sequence data is required to qualify for BERSS. For DNA … negotiation with the JGI.  Investigators with grants funded by DOE-BER requiring support from the JGI may  submit … initiative that seeks to reduce U.S. gasoline consumption by 20% within 10 years through increased efficiency and …

… Data produced and released by the US Department of Energy (DOE) Joint Genome Institute … protection of certain types of data to support their use by those generating data. The JGI Data Policy applies to … embargo starting at construct or strain delivery.  Detailed sequence information and constructs are made publicly …

… hard it was – it felt kind of like training for a marathon by running at a high altitude! And a lot of us moved on to … you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… capabilities support researchers exploring how to convert sequence into functional assessments. This is done by synthesizing genes, pathways, and whole chromosomes for … to validate hypotheses generated from mining genomic data by designing and assembling physical DNA constructs that can …

… we don’t recognize, because the only way to find things is by comparison. We’ll talk about that when we talk about … DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have …

… has been dominated for … well, as long as I can remember, by bacterial research.  So it was great to hear her passion … out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   … it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk …

… then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … called Salinospora . This new genus was discovered by friends and colleagues at the Scripps Institution of … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against …