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… product reports on the evolution of genome mining and microbes with Mohammad Alanjary and Tilmann Weber to be a … there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And I think … it would work, but we actually found fosmids. And we sequenced the whole fosmid at the time with Sanger …

… through analyzing and harnessing genomic information from plants, fungi, algae, non-medical microbes, microbial communities, and other relevant … in doing so enabled the JGI to be the first to publish the sequence analysis of the target chromosomes 5, 16, and 19, …

… we have our conversation with Professor Alison Narayan, from the University of Michigan. I hope she’ll accept this … enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh …

… we really recognize, right?  ALISON: And I tend to think of microbes as being able to secrete a lot more things than … DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have …

… Microbes drive critical ecosystem functions and affect … of phage and virus genomes have been assembled and reported from metagenomes, our understanding of the impacts of these … to identify, filter, cluster, annotate, and bin viruses from metagenomes. mSystems 9:e00888-24. …

… Laboratory. Being a User Facility means that scientists from all over the world bring us big problems related to … stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain … was adjacent to what I worked on, but my experience of how microbes are interacting in the environment like, like my …

… JGI serves more than 2,500 users that predominately come from the public sector: academic and government institutions … Our metabolomics platform delivers rich metabolite profiles from diverse biological and environmental samples by using … our User Program’s Community Science Program, the JGI sequenced and characterized 270 genomes of the Clostridium …

… genome mining on more than 50,000 genomes that we derived from meta-genome sequences. As always, you’ll find transcripts and show notes … for us– what organisms people use for genome mining, why it’s called genome mining, how the biosynthetic gene … review of early genome mining (pay-walled) A recent review from Constantini focused on drug discovery and newer …

… And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … them on a regular basis. So they are full of terrestrial microbes. So they’re open ecosystems. They’re not sealed off …

… at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … was looking to develop new methods for DNA sequencing of microbes. And what kept breaking our methods was these damn … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways …

… in the analysis and publication of the claimed genome sequences. This opportunity, provided by the Joint Genome … builds upon thousands of microbial genomes that have been sequenced by the JGI though not formally analyzed or … talent for biosciences.  Adopt-a-Genome has: ~20 faculty from institutions across the country Efforts in ongoing …

… use natural products necessarily. Fungi are large. They’re microbes, but they’re large microbes. And they have all … out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   … it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk …