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… it’s a little hard to find in print, but we live in the information age and the ebook version is available at most … able to explore DNA sequencing and actually get to the DNA sequence – sequences for the genes that code for the … Something that’s you know …  ALISON: Central! DAN: That’s why they called it that! But for, maybe, people who are less …

… the series of interviews we recorded at the Society for Industrial Microbiology and Biotechnology (SIMB) Natural … enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh …

… uses advanced sequencing technologies to decode the genomes of microbes in their natural environments. This work … research provides insights into microbial diversity and metabolic potential, with implications for energy production, environmental sustainability, and …

… DAN: Hey, everybody. Welcome back for another episode of Natural Prodcast. Right now I’m … of their synthases so that we can start to use the DNA sequence to predict or just understand better the language … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. …

… and scientists of secondary metabolism. Welcome back for our second season of Natural Prodcast. This first … more than 50,000 genomes that we derived from meta-genome sequences. As always, you’ll find transcripts and show notes … for us– what organisms people use for genome mining, why it’s called genome mining, how the biosynthetic gene …

… Marc was the Head of Experimental Genomics there, before he decided to leave for graduate school and pursue his … at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways …

… research is focused on the discovery and characterization of novel bacterial, archaeal and eukaryotic microbes and viruses in environmental sequence data. We use multi-omics (metagenomics, … to identify new divergent lineages and expand the Tree of Life. We then investigate the coding potential to find …

… I wanted to tell you about in this introduction. First and foremost, our interview this week is with Professor Brian … And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, …

… and the bacteria and how the chemistry is going back and forth between them is part of what fascinates me about what … does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to …

… of secondary metabolism.  DAN: Hey there and welcome back for Episode 8 of Natural Prodcast. This week, we have our … you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … Takemura, whose voice you’ll hear in a minute – we work for the US Department of Energy Joint Genome Institute, or … stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain …

… approaches to identify and characterize genomic information from uncultivated microbes and viruses. We develop computational approaches to sift through thousands of metagenomes for signatures of viruses and novel microbial lineages, and reconstruct metabolic properties encoded within those genomes. Our aim …