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… resequencing, RNA sequencing and epigenomics. Expansion of sequence space:  The JGI generates reference genomes from … of microbial communities based on their metagenome sequence, in the context of reference isolate genomes …

… right? BEN: Yeah, yeah. Well, we are at [10 to the] minus 12 [Molar concentration]- is sufficient to kill cells. So … the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very …

… capabilities and products . A minimum request of 1 Tb of sequence data is required to qualify for BERSS. For DNA … the minimum is 100 kb, and for metabolomics, at least 22 samples are required. If your proposed request falls … and personnel resources for genomic research and sequence-based science.  Projects include de novo generation …

… this policy) produced through all user projects accepted FY22 and later through the Community Science Program (CSP), … embargo starting at construct or strain delivery.  Detailed sequence information for constructs are made publicly …

… stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain … more about some of the background and sort of the reasons why we want to do this. And also to provide a little more … I have been in – working in secondary metabolism for almost 20 years now. Which when I did the math, that was a surprise …

… (see Auspice Statement below) for the generation of sequence or metabolomic data, DNA synthesized, and any other … annotation, comparative analysis, and interpretation of sequence, metabolomics, and functional genomics data types … for your proposal using your proposal's WIP ID (ex. 503582). Click on the correct proposal name on your search …

… at JGI start with sequencing, but where else did those sequences go? Like, what are the other scientific tools we … We don’t want to get a proposal that’s just asking for 20 microbial genomes. That is not a good fit for our annual … that describe the work. In general. Scientific merit and why it’s important. The DOE mission is one of these …

We focus our efforts on integrating database mining and sequence design with scaling the production of large, … developing methods for converting digital information from sequence databases into biotechnological or environmental …

… and eukaryotic microbes and viruses in environmental sequence data. We use multi-omics (metagenomics, … available at Google Scholar. Schulz, C Abergel, T Woyke (2022) Giant virus biology and diversity in the era of …

… through end-to-end automation, and further advancing sequence applications, single cell genomics, DNA synthesis, …

… tool BOOST , which provides a suite of tools to automate sequence design for assembly by Gibson, Yeast recombination …

… you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … I’ve seen you give a few talks on that. Can you tell us why cone snails are so cool? ERIC:  So cone snails are … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …