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… the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very … origin is around 30,000 from fungal, and a 40,000 from bacteria. Okay? And among the 40,000 from bacteria, there’s …

… about something I can kind of see like the squid and the bacteria and how the chemistry is going back and forth … does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to …

… fantastic diversity of cell types and associated organisms, including fungal and bacterial symbionts, detrimental microbial pathogens, and … better understand the plant-associated terrestrial world. Research Team    … Plant microbiomes hold the amazing ability …

The JGI has diverse capabilities in: DNA and RNA sequencing, Sample and library preparation, … sequencing products below. In addition, JGI will submit raw sequence data to  SRA at NCBI once the standard analysis is … in length, cloned into vector of choice Glycerol stock of sequence verified clone 102/NA DNA Synthesis Constructs …

… focuses on the exploration of secondary metabolites across bacteria, fungi, algae and plants. These molecules, which … growth, provide critical advantages to the organisms producing them, and are often involved in defense, nutrient … computational analyses of BGC size and complexity, BGC sequence composition, metabolic similarity & compatibility, …

Research in the Woyke laboratory focuses on the utility of … of microbial metabolism towards a minority of cultivated bacteria, still persists to date. Research Team    … … is also reflected in the strongly biased representation of sequenced genomes in the public domain, the bulk of which …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … chemical compounds that you find in plants, fungi and bacteria, basically all living things. When your crazy Aunt … stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain …

And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … in the marine ecosystems and marine actinomycetes and cyanobacteria. And we thought we could also– let’s see what caves …

… is focused on the discovery and characterization of novel bacterial, archaeal and eukaryotic microbes and viruses in environmental sequence data. We use multi-omics (metagenomics, …

… collaborative user projects, the JGI’s Plant Program delves into the natural world’s potential to address global … evolution. It also utilizes advanced tools, including deep learning algorithms for gene annotation and protein … manipulation in the laboratory. Both germplasm (sequenced mutants and natural accessions) and protocols …

The Metagenome Program uses advanced sequencing technologies to decode the genomes of microbes in their natural environments. This work encompasses bacteria, archaea, and micro-eukaryoes, along with their … comprising the largest public collection of plasmid sequences identified from genomes, SAGs, MAGs, metagenomes …

… through the stories I told you about geosmin, which is a bacterial sacred metabolite, and ergot alkaloids come from … DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have …