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… biology classes in undergrad, but my PhD was an actinobacteria. And I tell all my students this now, but when I … Duncan: Yeah. I love actinomycetes. Dan Udwary: Tell us why. I mean, I know, but I think– Alison Takemura: I want to … of almost finished characterizing them. We’ve got genome sequences, which are just incredible. We’ve looked at the …

… focuses on the exploration of secondary metabolites across bacteria, fungi, algae and plants. These molecules, which … interactions with their environments and with each other, from defending against predators to aiding in symbiotic … computational analyses of BGC size and complexity, BGC sequence composition, metabolic similarity & compatibility, …

… capabilities and products . A minimum request of 1 Tb of sequence data is required to qualify for BERSS. For DNA … with grants funded by DOE-BER requiring support from the JGI may  submit proposals here . Investigators … from lignin left over after biomass processing. Great Lakes Bioenergy Research Center , led by the University of …

… the product and deliverables as well as target cycle times from sample receipt to completion of standard analysis.  Raw … sequencing products below. In addition, JGI will submit raw sequence data to  SRA at NCBI once the standard analysis is … in length, cloned into vector of choice Glycerol stock of sequence verified clone 102/NA DNA Synthesis Constructs …

JGI Metabolomics Platform delivers rich metabolite profiles from diverse biological and environmental samples using … molecular profiles are generated for metabolites extracted from a variety of experimental samples, including organisms … as well as different types of environments (e.g. soil, lake).  A wide range of metabolites are identified using …

… about something I can kind of see like the squid and the bacteria and how the chemistry is going back and forth … does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to …

… about several different pieces of her work, including bacterial quorum sensing and its effects on regulation of … The genes are pretty much 100% identical. We don't know why one is expressed over the other. As far as whether we're … usually serve as dimers, and then they will bind to certain sequences of DNA. And when they bind to those certain …

… we have our conversation with Professor Alison Narayan, from the University of Michigan. I hope she’ll accept this … enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh …

… in their natural environments. This work encompasses bacteria, archaea, and micro-eukaryoes, along with their … regulation, and noncoding RNAs in microbiomes. The insights from this work have the potential to drive innovations in … comprising the largest public collection of plasmid sequences identified from genomes, SAGs, MAGs, metagenomes …

… been dominated for … well, as long as I can remember, by bacterial research.  So it was great to hear her passion and … out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   … it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk …

… such effort is targeted at environmental cells that are from candidate phyla, major branches in the phylogenetic … of microbial metabolism towards a minority of cultivated bacteria, still persists to date. Research Team    … … is also reflected in the strongly biased representation of sequenced genomes in the public domain, the bulk of which …

… through the stories I told you about geosmin, which is a bacterial sacred metabolite, and ergot alkaloids come from … DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have …