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… working with him.  We talk about his father, the legendary marine natural products chemist, Richard Moore, and get into … then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against …

… more than 50,000 genomes that we derived from meta-genome sequences. As always, you’ll find transcripts and show notes … for us– what organisms people use for genome mining, why it’s called genome mining, how the biosynthetic gene … come from all kinds of disparate environments. There’s some marine. There’s some soil samples. There’s human gut …

… at JGI start with sequencing, but where else did those sequences go? Like, what are the other scientific tools we … areas that are less of a focus, I would say. For example, marine research is not so much of a focus within BER … that describe the work. In general. Scientific merit and why it’s important. The DOE mission is one of these …

… organisms as had been originally thought. The Impact The Antarctic lakes are a “treasure trove” of unknown microbes … in understanding the genomic basis and ecological consequences of microbe-microbe interactions. Using metagenomes … native microbes. Metagenomes from enrichment cultures were sequenced and assembled by the JGI. From these assemblies, …

… of haloarchaeal metagenomes broadens understanding of Antarctic biogeography. The Science Haloarchaea flourish in … in learning how these microbes have learned to adapt from marine to hypersaline conditions by studying the microbial … Impact By collecting and sequencing dominant haloarchaeal sequences from six hypersaline lakes, researchers focused on …

… For sequencing projects, once work is under way, raw sequence data is released to NCBI’s Sequence Read Archive on a regular basis, in accordance with …

… enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh … DAN UDWARY: That’s weird. I hadn’t heard that before. Why is that? Why would that be the case? ALISON NARAYAN: …

… least, talk to us, first about my definitions of things and why I am wrong, and also talk about some of the great … think the terms we should be using for what we do are, and why there and why it’s important to make those distinctions. … to approach it is more related to what JGI does, which is sequence genomes. And we just published last year in the …

… And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … has to have a story. And it can be looking for drugs from marine organisms, in which case you get to go to exotic …

… is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … just not enough time and money. I mean, we have a huge marine fungal project in collaboration with Bill Fenical at … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a …

… the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very … or you know, you’ve run into challenges that demonstrate why this is so important. BEN:  Yeah. So I wouldn’t call it …

… stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain … more about some of the background and sort of the reasons why we want to do this. And also to provide a little more … of the fun things that I hope that I can express today is why secondary metabolism is interesting and why it is that …