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… enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh … molecule of water. DAN UDWARY: Mhm. So oxygenases, they’re oxidizing other molecules. ALISON NARAYAN: Correct. Correct. …

… of their synthases so that we can start to use the DNA sequence to predict or just understand better the language … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. … favorite bacterial community. For us, it’s these methane oxidizing bacterial communities that we like to look through …

… the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very … origin is around 30,000 from fungal, and a 40,000 from bacteria. Okay? And among the 40,000 from bacteria, there’s …

… cell types and associated organisms, including fungal and bacterial symbionts, detrimental microbial pathogens, and … This is a dynamic and complex ecosystem that includes bacteria, fungi, viruses. Resident viruses can be found in a … experimental characterization methods, in addition to bioinformatics tools to elucidate phage function in this …

… focuses on the exploration of secondary metabolites across bacteria, fungi, algae and plants. These molecules, which are not essential for fundamental growth, provide critical advantages to the … computational analyses of BGC size and complexity, BGC sequence composition, metabolic similarity & compatibility, …

… material of uncultivated taxa of interest. One such effort is targeted at environmental cells that are from … of microbial metabolism towards a minority of cultivated bacteria, still persists to date. Research Team    … … is also reflected in the strongly biased representation of sequenced genomes in the public domain, the bulk of which …

… biology classes in undergrad, but my PhD was an actinobacteria. And I tell all my students this now, but when I … Duncan: Yeah. I love actinomycetes. Dan Udwary: Tell us why. I mean, I know, but I think– Alison Takemura: I want to … of almost finished characterizing them. We’ve got genome sequences, which are just incredible. We’ve looked at the …

Takemura, whose voice you’ll hear in a minute – we work for the US Department of Energy Joint Genome Institute, or … chemical compounds that you find in plants, fungi and bacteria, basically all living things. When your crazy Aunt … stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain …

… been dominated for … well, as long as I can remember, by bacterial research.  So it was great to hear her passion and … out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   … it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk …

… sequencing, synthesis, and targeted metabolomics support for DOE-BER funded awards, including awards funded through  … capabilities and products . A minimum request of 1 Tb of sequence data is required to qualify for BERSS. For DNA … and personnel resources for genomic research and sequence-based science.  Projects include de novo generation …

… is focused on the discovery and characterization of novel bacterial, archaeal and eukaryotic microbes and viruses in environmental sequence data. We use multi-omics (metagenomics, … The ISME Journal. 8 (8), 1634-1644 … Publications … For further details, please reach out to the Group Lead …

… through the stories I told you about geosmin, which is a bacterial sacred metabolite, and ergot alkaloids come from … DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have …