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… are subject to a  two-year embargo starting at construct or strain delivery.  Detailed sequence information for constructs are made publicly …

… … For sequencing projects, once work is under way, raw sequence data is released to NCBI’s Sequence Read Archive on a regular basis, in accordance with …

… enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh … DAN UDWARY: That’s weird. I hadn’t heard that before. Why is that? Why would that be the case? ALISON NARAYAN: …

… more than 50,000 genomes that we derived from meta-genome sequences. As always, you’ll find transcripts and show notes … for us– what organisms people use for genome mining, why it’s called genome mining, how the biosynthetic gene … lots and lots of biosynthetic gene clusters. So, in the ABC portal here at JGI, ABC being the Atlas of Biosynthetic …

… of their synthases so that we can start to use the DNA sequence to predict or just understand better the language … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. … what we’re trying to do right now is develop the chassis strains that then we can port things into as well. DAN: Give …

… is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … And these organisms are pretty gnarly. We have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a …

The genes are pretty much 100% identical. We don't know why one is expressed over the other. As far as whether we're … usually serve as dimers, and then they will bind to certain sequences of DNA. And when they bind to those certain … ring systems. JACKIE: Why? Is it just because of ring strain or is it-- I guess, what's the efficiency between …

… least, talk to us, first about my definitions of things and why I am wrong, and also talk about some of the great … think the terms we should be using for what we do are, and why there and why it’s important to make those distinctions. … to approach it is more related to what JGI does, which is sequence genomes. And we just published last year in the …

… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … on, first species, Salinispora tropica . And we isolated a strain that produced something extremely potent in killing … forward to seeing the data when it finally gets off the sequencers. The pandemic has obviously slowed JGI down a …

And the light organ houses Vibrio fischeri, it’s one strain and there have been years and years and years about … does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to …

… about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean … on Streptomyces clavuligerus , which was an industrial strain, a Streptomyces strain, the bacterium, that had been …

… algae, examining both natural populations and engineered strains. This approach allows for the identification of key … The  1000 Fungal Genomes Project is a five-year project to sequence 1000 fungal genomes from across the Fungal Tree of … of fungi. Mycocosm enables users to navigate across sequenced fungal genomes, and to conduct comparative and …