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… DAN: You’re listening to the US Department of Energy Joint … stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain … more about some of the background and sort of the reasons why we want to do this. And also to provide a little more …

… DAN UDWARY: It’s been a while, but Natural Prodcast is back … at JGI start with sequencing, but where else did those sequences go? Like, what are the other scientific tools we … that describe the work. In general. Scientific merit and why it’s important. The DOE mission is one of these …

… The JGI’s Microbial Program focuses on using cutting-edge sequencing, annotation and analysis techniques to explore the vast and … The Microbial Program focuses on using advanced sequencing technologies to … resequencing, RNA sequencing and epigenomics. Expansion of sequence space:  The JGI generates reference genomes from …

… Overview The JGI provides sequencing, synthesis, and targeted metabolomics support for DOE-BER funded awards, … capabilities and products . A minimum request of 1 Tb of sequence data is required to qualify for BERSS. For DNA … The JGI is inviting researchers using the U.S. Culture Collection Network (USCCN) to …

… Data produced and released by the US Department of Energy (DOE) Joint Genome … Embargo : A period in which data is not publicly available in JGI systems or outside … For sequencing or metabolomics projects: data are subject to a  one-year embargo .  For each data or …

… DAN: You’re listening to the US Department of Energy Joint … you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

…   The Joint Genome Institute's DNA Synthesis Platform capabilities support researchers exploring how to convert sequence into functional assessments. This is done by … Check out our organism-agnostic CRISPR gRNA design tool  … BOOST provides a suite of tools to automate sequence design for assembly by Gibson, Yeast recombination …

… DAN: You’re listening to the US Department of Energy Joint … DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have …

… DAN: You’re listening to the US Department of Energy Joint … out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   … it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk …

… DAN: You’re listening to the US Department of Energy Joint … then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against …

… Dan Udwary: You’re listening to the Department of Energy … about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean …

… DAN: Hey Marcy!  ALISON: Hey Marcy?  MARCY: Hello. How’s it … does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to …