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… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … about his move to microbiology, about drug discovery and why it’s so hard to succeed, and we talk about an ongoing … bring it into the lab. And I think that criterion explains why the natural products in the ocean weren’t studied up …

… it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk … this and that. They’re doing all this 16S and I said, “Why don’t you just include the ITS too? It’s so easy to add … don’t talk about that. But that happens not infrequently. Why is that? It looks like it’s encoding an enzyme, there’s …

… biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean … had to scale also by orders of magnitude. And that’s why Satria figured out some new clever tricks to make an … metabolism or biosynthetic gene clusters, somebody thinking why don’t why don’t you just BLAST it? What are you doing? …

… does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … between chemistry and sequence to get anywhere. Like that’s why I say the more you know, the more you know because it … an assembly problem. But we don’t see them clustered. But why? Why not? We see the chemistry so what’s going on? So is …

… enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … DAN UDWARY: That’s weird. I hadn’t heard that before. Why is that? Why would that be the case? ALISON NARAYAN: It’s a great …

… for us– what organisms people use for genome mining, why it’s called genome mining, how the biosynthetic gene … there you go. [laughs] ALISON TAKEMURA: All the more reason why it could have been inspired by Super Smash Brothers. DAN … you understand those better. And it builds. And that’s why I keep saying “inflection point”. At a certain point, …

… polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … And that’s what I really wanted to do. And that’s why I came back to academia. And I set that up. And we … it’s an excellent point. So– BRIAN BACHMANN: So that was why– that’s a major focus of the group. Now, the cave …

… functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways … favorite examples of a secondary metabolite producer, and why they produce those metabolites? MARC: Well, I’m really … ALISON: That’s really cool. MARC: Yeah, yeah, right. That’s why we’re able to talk about these predator prey dynamics …

… your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. … JGI and this was before they were integrated. So I thought, why not feed it in there. And I went to group meeting and … AARON PURI: Yeah. No, you’re exactly right. So you can see why these are tightly regulated. DAN: For sure. For sure. …