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I have been in – working in secondary metabolism for almost 20 years now. Which when I did the math, that was a surprise … the bark of the yew tree, is where it was originally discovered. And so that sounds great. There’s a natural source, … then a few years later, a few years ago actually, they discovered that Taxol is also produced by a fungus that happens …

Laura.Selbmann©PNRA. All the sampling activities in Antarctica have been performed in the frame of italian … this information freely to the public databases. In 2004, the JGI established itself as a national user … and accelerating biosystem-design to spur scientific discovery. Projects focused on organisms for comparative …

Bacteria and Archaea has steadily been widening since 2005. This gap is also reflected in the strongly biased … as phylogenetic anchors for metagenomes studies.  While uncovering the metabolic potential of uncultivated lineages is … through global metagenomics.” Nature 578(7795): 432-436 (2020). Seshadri R., Leahy S. C., Attwood G. T., Teh K. H., …

… right? BEN: Yeah, yeah. Well, we are at [10 to the] minus 12 [Molar concentration]- is sufficient to kill cells. So … will open up a new year for targeted anti cancer drug discovery. DAN: Yeah, great. Are any of these antibody-drug … look at several natural product enediyne structures, Ben’s 2015 paper on genome mining for enediynes is one of my …

… … Metabolic processes and trophic interactions in Antarctic cryptoendolithic communities … CSP Large-Scale LOI #1 … CSP Large-Scale LOI #2 … CSP New Investigator Submission … CSP Functional … Genomics Submission … FICUS Example #1 … FICUS Example #2 …

FY2023 Spending Profile The JGI is funded primarily by the DOE …

… high-throughput sequencing of microbial communities to uncover the complex interactions and functions that shape … environment. These advances have led to groundbreaking discoveries in diversity and novel functions identified in …

We also talk about his move to microbiology, about drug discovery and why it’s so hard to succeed, and we talk about an … unpalatable. And we know that this is one of the major adaptations in the ocean. So it took a while to convince … in the ocean in terms of what these naysayers had said– (MOCK TONE) “nothing new there!” Well, we started finding …

I really became more and more interested in cancer drug discovery and pharmacology but I didn’t know how to get towards … say a clutch is probably the size of a golf ball and has 25 to 50 eggs. I’m guessing here.  DAN: Sure, sure.  MARCY: … have done some work at the polls or is it the Arctic or Antarctic but you’ve gone to retrieve some bacteria that …

IMG , GOLD and others for data annotation and submission Tracking, monitoring and expediting laboratory processing …

The JGI’s Metabolomics Program works to uncover the roles of small molecules in biological systems, … experimental manipulations while being simultaneously imaged and sampled.  Combining collected metabolomics data … but highly recommend using the workflow in  GNPS2 .   … In support of user science, the JGI Metabolomics …