Search

… of secondary metabolites across bacteria, fungi, algae and plants. These molecules, which are not essential … crop enhancement. The program aims to tap into the largely unexplored biochemical diversity within secondary … of secondary metabolites produced by bacteria, fungi, algae and plants. These compounds are key to organisms' …

… this conversation about 10 months ago. I was pretty green at the time and had some really tedious technical … it’s a result of an evolutionary process that has led into large chemical diversity because the function relates to the … I think the important thing to remember is that, thanks to genomics, we now know that it is very hard to find stuff …

… experiment types, with main focus areas being genome variation, transcriptomics and epigenomics. Our work varies in scope from the development of … ‘proof-of principle’ research projects to demonstrate new genomic capabilities. Our group also performs ‘proof-of …

… Science Program (CSP) provides the scientific community at large with access to high-throughput sequencing, synthesis, … Three calls fall under the umbrella of our CSP: The Large Scale call is for expansive projects that leverage a … PIs who have never led a JGI project, and the Functional Genomics call is for projects that translate genomic …

… a revolution brought on by rapid developments in genomics and other omics technologies.  The exponential … as well as the development of novel methods to enable large-scale comparative analysis, mining and visualization … Neri U. et al. (2022) Expansion of the global RNA virome reveals diverse clades of bacteriophages. Cell . …

… encyclopedia of enzymes at Aldridge that I could use to buy green uricase or “Wittig-ase” or whatever I was looking for. … mechanistic enzymology to natural product biosynthesis to genomics to directed evolution– but it’s just the– it really … active in a heterologous host. So what you really need is a large tool kit of pieces in order to put them together to …

… genes, some of these enormous genes that encode these very large enzymes. And I was like, OK, wow, these are really … that time. Dan Udwary: So we should probably just back up a tiny bit and just say what antiSMASH actually is and does. … of hooks into IMG’s data. IMG being Integrated Microbial Genomics at JGI, a large data set of bacterial genomes. And …

… encoded on a single molecule of mRNA – in two species of green algae, Chlamydomonas reinhardtii and Chromochloris … . “I was scrutinizing the genes of one of our species of algae and kept seeing what looked like mistakes by the gene … to these challenges.  DOE’s Office of Science is the largest supporter of basic research in the physical sciences …

… user and no granting of funds.    Proposal Call FICUS CSP Large Scale CSP New Investigator CSP Functional Genomics JGI-TMF Critical Minerals and Materials Status … with the JGI Investigators interested in translating genomic information to biological function Investigators …

… where, among lots of other things, he works on the Tiny Earth project, which you’ll hear him describe. [ Go … by watching Amanda Hurley’s presentation from the 2019 JGI Genomics of Energy & Environment Meeting.] He’s also a … you for that insight. DAN: So I suppose, coming up with large collections of new microbes and new activities, feeds …

… are in individual tubules.  And so these tubules are like tiny monocultures but the whole of the organ which is about … there from the bacteria that work against protistsproduce, algae and other types of settlers.  DAN: Yeah you would … assays is what those would be. The work that we do at larger scale in order to look at the chemistry a little bit …

… have fully decoded the genome of an oil-producing green alga, and demonstrated precise gene targeting in the … foundation for metabolic engineering in oleaginous algae. By creating a telomere-to-telomere nuclear genome … relationships than other algae, Auxenochlorella ’s reduced genomic complexity can accelerate the design-build-test …