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Gluconibacter .  And that got me back a little bit to redox enzymes and looking at gene regulation. And then from there, … in an obvious way. NIGEL MOUNCEY: We did a little bit of metagenome screening work and did find related clusters. But … 30 to September 1st. The link is found all over JGI’s web pages.  DAN: And I will put it in the show notes along with …

… marine natural products. And was at the university for over 40 years. There were four of us as kids in the family. I was … marine natural product biosynthesis and at the beginning stages of connecting molecules and genes. And then genomics … might make this molecule and predicting what kind of enzymes might be involved, and then being able to make those …

… exciting. And why chemistry is so far behind in that stage is it’s still really difficult to do natural products … structure information. You still need structure at this stage, and you still need to put that information into … It’s them that do it. They created the Wiki. They edit the pages. They add the content. They run the Twitter account. …

Right. Yeah. DAN: Alright, so a subset of proteins are enzymes. Enzymes are proteins that do chemical reactions. And so secondary metabolites come from reactions, of enzymes and sometimes those are referred to as “small …

… in Yu et al, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2004, 1253–1262, 70:3 ALISON TAKEMURA: And so did you succeed … ago. Non-ribosomal peptides, remember, are big, complicated enzyme systems that really just exist to pull an amino acid … if an order is uncultured (blue; represented only by metagenome-assembled genomes or MAGs) or cultured (gray; …

… of talks relevant to JGI science at PAG XXVII. On January 14, JGI Plant Program head Jeremy Schmutz and  KBase Co-PI … Response 7:27 PM Highlights from Genome of Miscanthus 7:45 PM Transcriptome Changes during Leaf Senescence in  …

… vision for a sustainable, bio-based economy. … Genome to Enzymes and Pathways focuses on discovering and characterizing enzymes and pathways vital to DOE missions. Using … biosynthesis, synthesizing and biochemically analyzing enzymes to support mission-driven research. Rapid Metabolic …

… the “Non-Ribosomal Peptide Synthetases” or NRPSs. These are enzyme systems that grab amino acids and stick them together … end, we took an approach that was kind of a simplified metagenome sequencing approach to pick this system apart.  … ended up doing was pursuing with Jacques Ravel, at TIGR, metagenome sequencing, which was very early days for that …