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… the exploration of secondary metabolites across bacteria, fungi, algae and plants. These molecules, which are not … reservoir of secondary metabolites produced by bacteria, fungi, algae and plants. These compounds are key to …

… us on that. You know, as an added benefit, the S. tropica species also makes an anticancer agent that today is in … metabolomics, and natural products in plants, fungi, and microorganisms. If you want to collaborate, let …

Fleming – the discovery of penicillin from the fungal species – probably told us that fungi could be very productive sources for, say, biological … metabolomics, and natural products in plants, fungi, and microorganisms. If you want to collaborate, let …

… nothing for. We’re also working on organisms, pathogenic fungi like Candida aureus in the lab and we work on … of infectious or inflammatory disease and these same species are being used not just by one generation but by … on how it’s traditionally formulated, that can have huge differences on the final outcomes of the chemistry, and thus …

… the function, I guess, in terms of, like, they’re related. So they’re like, yeah, there’s some part to the … the biosynthesis and the chemistry and those are all really closely related things in terms of, like, evolution, in … metabolomics, and natural products in plants, fungi, and microorganisms. If you want to collaborate, let …

… very quickly see, OK, which gene clusters and genomes are related to those known ones? And which groups or families of … that those things are doing the same thing, or at least are closely related. Marnix Medema: Yeah. Yeah, absolutely. And … metabolomics, and natural products in plants, fungi, and microorganisms. If you want to collaborate, let …

People wanted to understand what those were and how related they were to primary metabolism, and, as we … been shared for a long time by many, many bacteria – and fungi and plants. And so that’s the power and the promise … millions of years to find the precursor sequences. Those species are long dead. And if the DNA sequences have been …

… with Christian, I started getting a little bit more into fungi and learning the differences of all the genetic differences and then expanded … are novel. I mean, we have Streptomyces , but they’re new species. And they have very similar [genomes] to other …

… stainless steel steam-in-place reactors. And worked very closely with them in manufacturing to get things into … a very little bit of looking at spinosyns trying to find related clusters at Warp Drive, which I can say we didn’t. … and behold, here I am.  [LAUGHTER]  DAN: What do you see as differences in your leadership positions in industry versus …

… biogeochemistry, bioproducts. So we cannot work on health related projects. We really need to fit– a project needs to … scientific review. Reviewers are going to look really closely. Are they going to deliver? Do they have funding? … is needed. So we do collaborate with various PIs quite closely on their CSPs. But we can’t collaborate with every …

No, yeah, and then I think that having all these very, very related genomes, right – on their 16S level, they’re almost … a marine actinomycete bacterium. So they look kind of like fungi but also make these mycelia. They kind of look like … we’re thinking they’re obligate marine. There’s so far no species or no strains known that really grow in freshwater. …

… bacterial sacred metabolite, and ergot alkaloids come from fungi, and Taxol from plants. Plants, fungi, bacteria, archaea, they all have secondary … – that nature has made to make different molecules that are related to primary metabolites. And they often use primary …