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… including User Facilities like the JGI, through its Genesis Mission. Launched in 2025, the initiative aims to … and AI agents to solve key national challenges. The Genesis Mission consortium will connect leading industry and … among members that catalyze data flows and promote novel data applications. As a large-scale data generator, …

… my undergraduate in microbiology and then PhD in microbial genetics in the UK. And came across to the US for a couple … spheroides . And that got me really interested in microbial gene regulation and some pathways. And I thought I’d take an … in people’s screenings. And the original isolate was found on an old rum still, which– you’ve got this very …

… and he has a project with the JGI to synthesize the genes for and explore the chemistry of quorum sensing … to identify what’s being made. In some cases it might be novel, in some cases it might be– might be a known structure … AARON PURI: Yeah. Yeah. So the more recent one that they found, which has a lot more structural diversity — so that …

… products is that we don’t know what all the biosynthetic gene clusters look like.  DAN: For sure.  MARCY: We have so … We find chemistry that’s known, or sometimes novel, but often known, and yet the clusters don’t look the … in the same place on the chromosome then you’ve definitely found a biosynthetic gene cluster.  And so those are really …

… lot of like synthetic chemistry effort to create a bunch of novel compounds that actually didn’t pan out. DAN: And there … and actually get to the DNA sequence – sequences for the genes that code for the proteins that produce secondary … that came out of investigating those genes is that it was found that most biosynthetic genes are found clustered in …

… Program supports a wide range of projects, from single-gene synthesis to the synthesis of entire chromosomes, … the program enables the design and synthesis of complex genetic pathways and biosystems. It The program fosters … in advancing functional genomics, focusing on developing genetic systems that can address global energy and …

… this conversation about 10 months ago. I was pretty green at the time and had some really tedious technical … the active site of an enzyme. So there is no promiscuity, generally speaking, in primary metabolism. Nevertheless, … antibiotic is really an antibiotic in nature, what is the general belief is that that is the case when there is a …

… The Joint Genome Institute and the Molecular Foundry have launched a joint Critical Minerals and … Access to the Molecular Foundry and use of JGI capabilities is free. The JGI … such as fully annotated genome assemblies or differential gene expression results. For DNA synthesis projects, JGI …

… that produces those. So it’s not a hard and fast rule, but, generally, animals do not have secondary metabolism that we … often use primary metabolites as building blocks to produce novel molecules. And so we’ve got glycosides being made into … went on the hunt for other similar bacteria or fungi, and found them. And that’s why penicillin saved millions of …

… thousands of metagenomes for signatures of viruses and novel microbial lineages, and reconstruct metabolic … This process enables our users to explore the genetic makeup of microbial communities, shedding light on … monitoring, bioremediation, and the discovery of novel enzymes and bioactive compounds. …