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… FY 2026 DOE Metrics Sequencing Quarter Total Bases (Trillions) Operating Hours …     Q4 2026 175     2,208     *Includes Illumina and PacBio sequencing platforms. **Operating Hours target is based on … even though an individual may have several projects/roles. Sequencing Quarter Total Bases (Trillions) Operating Hours …

… Bill Fenical. And we connected to JGI through the Community Sequencing Program, and they worked with us to sequence two … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against … might make this molecule and predicting what kind of enzymes might be involved, and then being able to make those …

… The JGI has diverse capabilities in: DNA and RNA sequencing, Sample and library preparation, DNA synthesis … of standard analysis.  Raw data is provided for all sequencing products below. In addition, JGI will submit raw … have been  discontinued , including smRNA, bisulfite sequencing, and ChIP-seq. …

… But on the other hand, we're also really interested in enzymes to do some of the reactions that chemists find … The genes are pretty much 100% identical. We don't know why one is expressed over the other. As far as whether we're … technology.] BETSY PARKINSON: OK. DNA affinity purification sequencing. And so the way this essentially works is you …

… started collaborating with Ben and his group to work on sequencing, synthesis and genome mining technology to help … the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … why the stereochemistry was that way. And he told me, it’s enzymes. It’s magic.  BEN:  Yeah, right.  DAN: I thought …

… it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk … everything is funding, right, isn’t it? I thank JGI for sequencing a lot of fungi. But the thing with them – to get … backbone gene synthases, but having a different decoration enzyme actually could give you something that’s quite …

… which was a very early genome mining company, back when DNA sequencing of natural product pathways was hard and … microbiomes, and using engineered biosynthetic pathways and enzyme systems to do synthetic analoging of some really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, …

… For sequencing or metabolomics projects: data are subject to a  … Sequencing and Metabolomics projects …

… other omics technologies.  The exponential growth of DNA sequencing data, coupled with recent computational … (Nature 2019). Other projects in the group include the sequencing and comparative analysis of thousands of archaeal … et al. (2014) Genomic Encyclopedia of Bacteria and Archaea: Sequencing a Myriad of Type Strains. PLoS Biology …

… your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. … you could think of designing one of those that can trick an enzyme into thinking that that’s its substrate. And then … JGI and this was before they were integrated. So I thought, why not feed it in there. And I went to group meeting and …

… they need to grow and divide. Similar to the bacterial enzymes that fix nitrogen — nitrogenases — other enzymatic … has potential as an industrial workhorse. As these enzymes cleave the sulfur from gasses, they also produce … done the synthesis, metagenome mining, all the way from sequencing to functional characterization, and a project …

… and the 90s. And so we started to be able to explore DNA sequencing and actually get to the DNA sequence – sequences … Something that’s you know …  ALISON: Central! DAN: That’s why they called it that! But for, maybe, people who are less … Right. Yeah. DAN: Alright, so a subset of proteins are enzymes. Enzymes are proteins that do chemical reactions. …