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Hey Marcy!  ALISON: Hey Marcy?  MARCY: Hello. How’s it going?  DAN: Good. How are you?  MARCY: Am fine. I live in a … certainly the goal. I think with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to …

… right. Welcome back to Natural Prodcast. I did it. I’m keeping to my schedule. This should be coming out on the first … they won't. They've been turned these clustered situated regulons, but that might not be quite as true as we once … usually serve as dimers, and then they will bind to certain sequences of DNA. And when they bind to those certain …

Research in the Woyke laboratory focuses on the utility of … of microbial metabolism towards a minority of cultivated bacteria, still persists to date. Research Team    … … is also reflected in the strongly biased representation of sequenced genomes in the public domain, the bulk of which …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … through the stories I told you about geosmin, which is a bacterial sacred metabolite, and ergot alkaloids come from … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have …

… strengthens -omics technologies at the JGI by identifying the actual molecules present in an environment that influence system behavior.  Through this identification, metabolomics enables functional genome …

… back to a new session of Natural Prodcast. I’ve got two things I wanted to tell you about in this introduction. First … which was a very early genome mining company, back when DNA sequencing of natural product pathways was hard and … and expressing cryptic metabolic pathways” On target identification and cancer biology: “Apoptolidin family …

FY2023 Spending Profile The JGI is funded primarily by the DOE Office of … Biological and Environmental Research (BER), a program within the DOE Office of Science. …

… for another episode of Natural Prodcast. Right now I’m working on this the afternoon of the day I’m due to release it, … of their synthases so that we can start to use the DNA sequence to predict or just understand better the language … Cummings DA Jr. Methylotroph Quorum Sensing Signal Identification by Inverse Stable Isotopic Labeling . ACS …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … And a lot of us moved on to work in simpler systems, like bacteria, where we figure we can make more progress faster, … took an approach that was kind of a simplified metagenome sequencing approach to pick this system apart.  DAN:  And …

Program works to uncover the roles of small molecules in biological systems, linking them with genomic data to enhance our understanding … experimental manipulations while being simultaneously imaged and sampled.  Combining collected metabolomics data …

Hey, Alison Takemura: Hey, Dan. Dan Udwary: Today we’re going to talk to Kate Duncan. And Kate is– I should ask, you … before– or kind of around about when the first genome sequencing was done. But natural products– marine natural … biology classes in undergrad, but my PhD was an actinobacteria. And I tell all my students this now, but when I …

Biology is currently experiencing a revolution brought on by rapid developments in … other omics technologies.  The exponential growth of DNA sequencing data, coupled with recent computational … Nature . 622(7983):594-602. Camargo AP. et al. (2023) Identification of mobile genetic elements with geNomad. Nat …