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… metabolism and secondary metabolism, and we talk about the early history of the field. Then, in the third episode, … pilgrims if they’re up there? I don’t know.  DAN: Maybe early colonists? Yeah. ALISON: Wow, that’s nuts. I had not … a cancer drug. It was the largest selling drug back in the early 2000s for cancer. You know, a billion dollar drug. But …

… a lot of ground – her book, bioprospecting vs biopiracy, early stage drug discovery in general, and a possible … I mean you have to secure an agent and there’s all these steps and it’s kind of a mystery of how you get there. And I … technologies, NMR, mass spec, whatnot and then we’re comparing that to see what we’re able to pick out through …

… yes, sure, right. And yeah, so we worked on the Salinospora genomes. That was a really fun project. We had Brad on and he kind of waxed poetic about the early parts of the project. How did that postdoc where– I … ALISON TAKEMURA: And this is Paul Jensen in the early 2000s? Late 2000s? NADINE ZIEMERT: No, yeah, 2010. …

… to a particular producing organism in the context of a clearly defined ecological interaction. So it’s not central … bit more intuition about how you go from the expansion to comparing to the database. Is it like, let’s say I’m drawing … behind these stories, because what we want to learn are lessons that can be translated into applications, not the …

… open up our field to other study. And so it was kind of an early example, to try to open that microbiome field. In the … Ravel, at TIGR, metagenome sequencing, which was very early days for that technology. And we found the pathway. …

… got this very sugary environment. It’s a compound that clearly kills things that would otherwise consume substrates … last time I really worked in the lab. It was on the very early work of cultivating this guy and figuring out how to …

… and environmental sustainability. … Plant Flagship Genomes are selected through discussion with the JGI Plant … Advisory Committee and DOE, designating a set of JGI plant genomes that are the most important to DOE mission and plant … datasets to further gene function research. The  Open Green Genomes (OGG) project seeks to develop comparative high …

… the science of natural products, and we dive into the very early history of the field. If you continue on, in the next … that’s maybe obvious or notable. We are still in – not an early stage. I think we can identify most secondary … and you can see that different Frankia have different size genomes depending on what kinds of plants, and what kinds of …

JGI also sustains a vibrant community of postdoctoral and early career researchers. …