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… for researchers to request the capabilities and expertise of both national user facilities in one research proposal.  … challenges in the sourcing, recovery, and utilization of critical minerals and materials. The proposal submission … to the Molecular Foundry and use of JGI capabilities is free. The JGI supports remote users. Users conduct …

… are complex organisms that harbor a fantastic diversity of cell types and associated organisms, including fungal and … tools to study this complexity, including single-cell and spatial transcriptomics barcode-based genetics … omics technologies, strain engineering and experimental characterization methods, in addition to bioinformatics …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … is always associated with toxicity, basically, killing cells. ALISON: Right, because they’re so reactive. BEN: … how nature is making compounds, but we are also applying CRISPR technology, anything as genome editing, genome …

… DAN: Hey, everybody. Welcome back for another episode of Natural Prodcast. Right now I’m working on this the … predict or just understand better the language of microbial cell-cell communication. And he told us about his work in … I know that there’s a lot to be said about for free living ones this idea that maybe they’re gardening who …

… to more easily integrate the expertise and capabilities of multiple Department of Energy Office of Science National … synthesis, metabolomics and analysis will be provided for free to the PI by the Department of Energy’s funding of the … provides customized analysis, the JGI also participates in publication of results. …

… and predictive biology, modeling and biodesign — questions of relevance to DOE’s Biological and Environmental Research … While applications will be accepted that address any aspect of these mission areas, priority will be given to projects … synthesis, metabolomics and analysis will be provided for free to the PI by the Department of Energy’s funding of the …

… of a cave. So it just– it really, really, really falls rapidly. But we eventually– after testing all these … mammalian systems. But it allows us to assay on a single cell level against cell lines and against primary cells … So you can knock out an acyltransferase and then use a free hydroxyl group and do some chemistry and get around …

… initiatives new to the JGI. Projects must be independent of ongoing JGI proposals, and lead PIs cannot have been lead … projects will provide pilot data to assess feasibility of a novel approach or form the foundation for a large-scale … synthesis, metabolomics and analysis will be provided for free to the PI by the Department of Energy’s funding of the …

… Micro-Scale Applications group explores the genetic makeup of natural microbial communities using a variety of … technology in order to enhance the quality of single-cell genomes and directly link functional information with individual cells. Research Team    …

… been described in such detail. DAN UDWARY: Alison, feel free to jump in with questions. But otherwise I’m going to … that the molecules out there would be toxic to cancer cells. And that started something big. Because at that time, … normal cells, particularly your hair cells, which are also rapidly growing, the cells in the mucosa lining of your …

… Software engineers in the Synthetic Biology Informatics Group develop, deploy, and maintain software that support the JGI’s Synthetic Biology Program .  … software includes: gRNA-SeqRET , an organism-agnostic CRISPR gRNA design tool BOOST , which provides a suite of …