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The focus of this group, in recent years, has been to bring generalizable technologies to … a taxonomically diverse suite of microbial chassis strains for elevated opportunity for expression. Research Team    … …

The Joint Genome Institute's DNA Synthesis Platform capabilities support researchers exploring how to … functional assessments. This is done by synthesizing genes, pathways, and whole chromosomes for bioenergy, nutrient … user project design, assembly, and quality control Strain Engineering Group : a research & development group and …

… we can use that knowledge to actually use it in drug discovery, right? I mean, at the end, we somehow have the … There’s gene fusion going on, and then I could see how the pathway gets streamlined and becomes more effective. That’s … Usually, in a lot of cases, we still have to go through publications to get proteins, and their functions, and all …

… tools and how to really access and manipulate these pathways to get new compounds. And lots of– had some really … in natural products, and especially if you’re in the drug discovery angle, is to look in industry. But you’re a … And I think a lot of times, too, when we even look at publications, it’s always positive data, right? No one ever …

… algae and plants. These molecules, which are not essential for fundamental growth, provide critical advantages to the … these hidden biochemical resources by exploring the genetic pathways responsible for their synthesis. The Secondary … characterization, the program strives to facilitate the discovery of new bio-based molecules that can drive …

… … DAN UDWARY: Hey, everyone. I’ve got a great episode for you here today. We got the opportunity to talk to one of the real legends of natural products, Professor Bill … We also talk about his move to microbiology, about drug discovery and why it’s so hard to succeed, and we talk about …

… and resources. Our vision is to lead genomic innovation for a sustainable bioeconomy. ALL PROPOSALS must support the … of genome biology and develop the genome-scale engineering technologies needed to design, build, and … and accelerating biosystem-design to spur scientific discovery. Projects focused on organisms for comparative …

… … Dan Udwary: Hey everybody! Welcome back for Natural Prodcast episode 17. The guest we have this week … with a broad range of experimental work on plants for drug discovery in antibiotics, anticancer, and now COVID. We also … I think on COVID that we’re getting ready to submit for publication and have found some interesting hits for that as …

… the only way a primary metabolite or a primary metabolic pathway is good for anything, it is if the final product is … about being able to do. FRANCISCO BARONA-GOMEZ: Yeah, truly engineering and going beyond what nature has evolved, which … of natural product biosynthesis in bacteria ” The ActDES publication came out after we talked. It looks like a great …

… it, but it has a really fun and interesting biosynthetic pathway, and I’ll have to do a whole show on it one of these … in that. And we have a project working on pain drug discovery from those animals. A second area that I’m really … you’d like to read more about this, I highly recommend his publication last year, “The Biosynthetic Diversity of the …

Every approved proposal starts with a User Agreement — before any work can begin, including the submission of samples for sequencing, or the submission of sequencing … rights in technical data, project reporting to the DOE, and publication requirements. An official with authority is …

… analysis techniques to explore the vast and diverse world of microbes. Studying bacteria and archaea, including those … inter-organismal interactions. These insights are crucial for addressing key environmental challenges, such as … This effort uncovers novel genes, protein families, and pathways, enhancing our understanding of evolutionary …