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… always been the main driver for secondary metabolism drug discovery. Because we always need new antibiotics. We need … and how we do it here and maybe give an example of a recent publication. ALISON TAKEMURA: Awesome. Yeah, let’s dive in, … cluster. And so we’ve learned a lot about how biosynthesis pathways happen, just by being able to find one kind of gene …

… sequencing, Sample and library preparation, Biodesign and pathway engineering Mass spectrometry based metabolomics Below is a … to completion of standard analysis.  Raw data is provided for all sequencing products below. In addition, JGI will … DNA Synthesis Constructs >10kb in size Gene clusters or pathways totaling more than 10kb in length assembled …

… we can use that knowledge to actually use it in drug discovery, right? I mean, at the end, we somehow have the … There’s gene fusion going on, and then I could see how the pathway gets streamlined and becomes more effective. That’s … Usually, in a lot of cases, we still have to go through publications to get proteins, and their functions, and all …

… Our research is focused on the discovery and characterization of novel bacterial, archaeal and eukaryotic microbes and … Exploring the fascinating world of giant viruses, which challenge our understanding of viral … insights into viral evolution and complexity, and encode for a treasure trove full of novel genes ready to be tapped …

…   The Joint Genome Institute's Biodesign Platform capabilities support researchers exploring how to … functional assessments. This is done by synthesizing genes, pathways, and whole chromosomes for bioenergy, nutrient … user project design, assembly, and quality control Strain Engineering Group : a research & development group and …

… tools and how to really access and manipulate these pathways to get new compounds. And lots of– had some really … in natural products, and especially if you’re in the drug discovery angle, is to look in industry. But you’re a … And I think a lot of times, too, when we even look at publications, it’s always positive data, right? No one ever …

…   The JGI’s Secondary Metabolites Program focuses on the exploration of secondary metabolites across bacteria, fungi, algae and plants. These molecules, which are not essential for fundamental growth, provide critical advantages to the … these hidden biochemical resources by exploring the genetic pathways responsible for their synthesis. The Secondary …

… DAN UDWARY: Hey, everyone. I’ve got a great episode for you here today. We got the opportunity to talk to one of the real legends of natural products, Professor Bill … We also talk about his move to microbiology, about drug discovery and why it’s so hard to succeed, and we talk about …

… Research in the Eloe-Fadrosh group focuses on using … approaches to identify and characterize genomic information from uncultivated microbes and viruses. We develop computational approaches to sift through thousands of metagenomes for signatures of viruses and novel microbial …

… Dan Udwary: Hey everybody! Welcome back for Natural Prodcast episode 17. The guest we have this week … with a broad range of experimental work on plants for drug discovery in antibiotics, anticancer, and now COVID. We also … I think on COVID that we’re getting ready to submit for publication and have found some interesting hits for that as …

… Overview The JGI provides sequencing, synthesis, and targeted metabolomics support for DOE-BER funded awards, including awards funded through  … ,  Science Focus Areas  (SFA) opportunities, and the  Office of Science Early Career Research Program .   If … Collection Network (USCCN) to nominate their strains for sequencing, as long as they have a scientific question …

… Mexico, and an incredibly bright guy who’s been thinking for a long time about the evolution and natural products … the only way a primary metabolite or a primary metabolic pathway is good for anything, it is if the final product is … about being able to do. FRANCISCO BARONA-GOMEZ: Yeah, truly engineering and going beyond what nature has evolved, which …