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… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … molecules can bind to different places, but then the ring opening can cause all kinds of crazy havoc depending on what … to kill cells. So it’s really remarkable in terms of a novel mechanism, how a small molecule can kill. So that …

… time called Genbiotics , which was a large program to find novel antibiotics. And this particular project focused … working with Tilmann on this. But this also has become very open to the community as well, so the versions of antiSMASH … clusters. And then they sequenced a really nice and good assembly. They were able to assemble a really high quality …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a podcast about the … with a fungus than putting it into a bacterium. It would open the doors to be able to start looking at some of these … This is episode 4 of Natural Prodcast, our interview with Dr Nancy Keller from …

… analysis techniques to explore the vast and diverse world of microbes. Studying bacteria and archaea, including those … associated with microeukaryotes, enhances our understanding of terrestrial biogeochemical cycling and inter-organismal … in particular to study inter-organismal interactions. Novel approaches are being explored to predict microbial …

… Mass spectrometry based metabolomics Below is a table of standard product offerings, including a description of the product and deliverables as well as target cycle … Lower coverage short-read whole genome shotgun sequencing Assembly, annotation ( Mycocosm ) 256/404 Fungal Standard …

… Data produced and released by the US Department of Energy (DOE) Joint Genome Institute (JGI) are subject to the following Data Policy. It is our mission to support open data and information sharing. We also recognize the … PIs or co-PIs) who wish to include use-restricted data in publications, or who wish to redistribute data in any way …

… synthetic biology applications group. The DNA synthesis and assembly group: Our production group operates as user facility that aims to provide access to state-of-the-art DNA synthesis and assembly technologies to the … applications.  We are interested in:  characterizing novel enzymatic activities using phylogenomic driven …

… DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast, a … Usually, in a lot of cases, we still have to go through publications to get proteins, and their functions, and all … made it. That was good luck. I mean, I’m still proud of the strategy, how we found the gene cluster. But had they then …

… for researchers to request the capabilities and expertise of multiple DOE National User Facilities in one research … Successful applications will focus on high-risk/high-payoff proposals within the focused topic areas that can be … provides customized analysis, the JGI also participates in publication of results. …

… DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast– a podcast about natural … bright guy who’s been thinking for a long time about the evolution and natural products systems. This conversation … of natural product biosynthesis in bacteria ” The ActDES publication came out after we talked. It looks like a great …

… joined the JGI in 2017, he brought with him 20 years of industry experience — and an opportunity to expand the … among members that catalyze data flows and promote novel data applications. As a large-scale data generator, … accessible, AI-ready large-scale data repositories for genome information with analysis tools for mining and …

… to get you through the day. So for me, it was if a door opens, take an opportunity to explore it, and you’ll find … seems to be a new structure, and the microorganisms are novel. I mean, we have Streptomyces , but they’re new … And I think a lot of times, too, when we even look at publications, it’s always positive data, right? No one ever …