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… to current problems facing humanity. A major focus are biofuel feedstock species and plant-microbe interactions, … a plant based bioeconomy where plants are a major source of chemical production and contribute to a healthier planet … — from understanding how terrestrial plants and phytoplankton capture atmospheric carbon, helping to regulate …

… at usermeeting.jgi.doe.gov . And I’ll be sure I put that link in the show notes, which you can always find through the … my undergraduate in microbiology and then PhD in microbial genetics in the UK. And came across to the US for a couple … help the Society grow. And so I’ve been the chair of the publications committee for the last, what is it now, five …

… remind you, you can get transcripts, and show notes with links to papers around the science we talked about, at natural … other and then up-regulate or trigger some of these cryptic clusters or these biosynthetic clusters we don't really know … oftentimes will bind to receptors within biosynthetic gene clusters. Specifically, these are Tet repressors that …

… Below is a brief description of the process needed to prepare and ship samples for … sample QC requirements and protocols Obtaining DNA and RNA of suitable quantity and quality has been the rate-limiting … step for many projects at the JGI. The quality of the starting material is one of the greatest predictors …

… analysis techniques to explore the vast and diverse world of microbes. Studying bacteria and archaea, including those … associated with microeukaryotes, enhances our understanding of terrestrial biogeochemical cycling and inter-organismal … environments using single cell approaches. This includes linking strain-level genetic variation to ecological niche …

… on evolution of natural products biosynthesis. I think it will be fun to be able to provide a semi-regular forum … that can’t live without their host. They have no extra genes hanging around, they still dedicate 20-30% of their … papers [on] recently – on evolution of biosynthetic gene clusters. And you and I have had some arguments over beers …

… The Fungal & Algal Program explores the vast diversity of fungi and algae to unlock their potential for bioenergy, … and bioproducts. By sequencing and analyzing the genomes of these organisms, the program investigates the biological … into practical applications, including sustainable biofuels, biomaterials, natural products, and environmental …

… in – like I can sort of see when I’m doing the work or thinking about something I can kind of see like the squid and … And we’ve done some work with those and have a couple of publications out there on the chemistry. There’s so much … products is that we don’t know what all the biosynthetic gene clusters look like.  DAN: For sure.  MARCY: We have so …

… a big international community effort, and I want to say thank you, personally, to everyone involved in making this … America brought to the UK? ROGER:  Yeah, it’s difficult to generalize, of course, but I felt overall that the British … perspective, JGI has a large database of biosynthetic gene clusters and biosynthetic gene cluster fragments, and all …

… Streptomyces are nature's chemical factories. They hold genetic blueprints for dozens of complex compounds, but stay … in a dedicated set of genes called a biosynthetic gene cluster. However, most of these gene clusters remain silent … clusters themselves. The team also identified previously unknown promoter sequences within these gene clusters, …

… Research in the Woyke laboratory focuses on the utility of single-cell methods to access genetic material of uncultivated taxa of interest. One such … that are from candidate phyla, major branches in the phylogenetic tree without cultivated representatives. The “Great …

… in graduate school.    NANCY: Forced to!   DAN: No, I think your stuff was really important to forming my concepts of … After I got my undergraduate degree, which was in general biology, I joined the Peace Corps. And when I was … with, you know, weirdness in the sequence. You know, some clusters are not clustered…   NANCY: Right. I think that put …