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… DAN UDWARY: So Alison, I’m really excited today. We have, by far, I think, one of the most decorated and legendary … that they needed to consider chemical impact on species interactions, communication, that kind of thing. But … do the full genomes for us. So fortunately, the secondary metabolite component of the JGI, people are interested in …

… Nigel Mouncey, started and leads the JGI’s Secondary Metabolites Science Program, which I was hired into, and my … is the first episode, and at the same time I’m going to release 5 other episodes so you can get a good feeling for … search away! If you like these primer episodes, let me know by emailing us to [email protected], or on twitter @JGI or …

… se, how do you see genome mining and looking for secondary metabolites in the genome as relevant to the JGI mission? … and how we do it here and maybe give an example of a recent publication. ALISON TAKEMURA: Awesome. Yeah, let’s dive in, … out, or maybe it’s just come out by the time this gets released. And that you got to do some genome mining for that …

… approaches to assess microbial activity across ecosystems.  By studying microbial communities and their interactions, the Program aims to unlock the fundamental … research provides insights into microbial diversity and metabolic potential, with implications for energy …

… bacterial, archaeal and eukaryotic microbes and viruses in environmental sequence data. We use multi-omics (metagenomics, metatranscriptomics, single cell genomics and phylogenomics) and machine learning to identify new divergent lineages and expand … Exploring the fascinating world of giant viruses, which challenge …

… term you prefer. In this episode we’re going to finish up by talking about the modern, post-golden age history of … the genes that code for the proteins that produce secondary metabolites. Do you recognize this? DNA 🡺 RNA 🡺 Protein … is doing a chemical reaction. And then the final product is released. And you’ve got this molecule called erythromycin, …

… Data produced and released by the US Department of Energy (DOE) Joint Genome Institute (JGI) are subject to the following Data … Embargo : A period in which data is not publicly available in JGI systems or … PIs or co-PIs) who wish to include use-restricted data in publications, or who wish to redistribute data in any way …

… of the Joint Genome Institute and head of the Secondary Metabolites Science Program at JGI, and also my boss, Nigel … with my boss, JGI Director Nigel Mouncey. DAN: I’ll start by saying this is the first in-person recording that I’ve … help the Society grow. And so I’ve been the chair of the publications committee for the last, what is it now, five …

… are those– they make chemistry! And so they – secondary metabolites, specialized metabolites, however we want to … And we’ve done some work with those and have a couple of publications out there on the chemistry. There’s so much … you bring a unique perspective too? And so I was fascinated by – we spend a lot of time as natural products chemists and …

… can you tell me the story of how you got into secondary metabolites? Kate Duncan: So I always liked science in … people that wants to study oceanography and was fascinated by the oceans, though I’ve always lived by the sea in the … is a whole bunch of information that maybe never makes its publication. And these are little tips, you know, how to …

… ZIEMERT: Big picture, I want to understand how secondary metabolites evolve– who makes them, how do they spread, why … around us. And we actually don’t know a lot about them by their mate, what their role in nature, how have they been … Usually, in a lot of cases, we still have to go through publications to get proteins, and their functions, and all …

… metabolism and centralized metabolism, or what a secondary metabolite is versus what a specialized metabolite is, then … usage. And I was recently challenged on that on Twitter by Francisco Barona-Gomez. And so he is here to, at least, … about it, the only way a primary metabolite or a primary metabolic pathway is good for anything, it is if the final …