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… DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast– a … BARONA-GOMEZ: I think that the very first thing that got us into this is that we should, in any case, use definitions … move a little bit away from that to try to unmask chemical dark matter. And the idea behind this is that, if we …

… here today, and we wanted to talk to her about a whole list of things. So we have a Scripps background shared together, … question. Kate, can you tell me the story of how you got into secondary metabolites? Kate Duncan: So I always liked … is a whole bunch of information that maybe never makes its publication. And these are little tips, you know, how to …

… DAN: Hey, everybody. Welcome back for another episode of Natural Prodcast. Right now I’m working on this the … have to see if I’m going to slip a day on releasing it into the feeds, but I’m trying, you guys. Schedules are … to identify what’s being made. In some cases it might be novel, in some cases it might be– might be a known structure …

… The JGI’s Metabolomics Program works to uncover the roles of small molecules in biological systems, linking them with … genomics with metabolomics fuels the discovery  of novel metabolites, genes, and proteins. It also enables … exploration of energy and nutrient exchange, as well as microbial and plant responses to environmental changes. With …

… are complex organisms that harbor a fantastic diversity of cell types and associated organisms, including fungal and bacterial symbionts, detrimental microbial pathogens, and associated viruses that all … fungi, viruses. Resident viruses can be found in a myriad of bacterial strains, whereby they can modulate host …

… know that that’s ever necessarily like a good description of anyone because chemistry means a lot, especially when … work we’ve determined that the ANMG deposits those bacteria into the jelly coat of the eggs. And so these eggs are laid … And we’ve done some work with those and have a couple of publications out there on the chemistry. There’s so much …

… for you here today. We got the opportunity to talk to one of the real legends of natural products, Professor Bill … Bill is a pioneer of marine natural products, getting into the ocean and looking for molecules from the very … an exploration into the secondary metabolism of some more novel marine bacteria. You know, I first met Bill as a …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … with a ribosome. Then, some other enzymes chop the protein into smaller pieces, and other enzymes might make other kids … And so we’ve been working on that. But why small molecules matter is because this pain drug, this peptide that’s used, …

… starts with a User Agreement — before any work can begin, including the submission of samples for sequencing, or the submission of sequencing … rights in technical data, project reporting to the DOE, and publication requirements. An official with authority is …

… Dan Udwary: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast, a … it will be really good to maybe start with how did you get into this field? How did you get into natural products? … time called Genbiotics , which was a large program to find novel antibiotics. And this particular project focused …

… The Facilities Integrating Collaborations for User Science (FICUS) call … for researchers to request the capabilities and expertise of multiple DOE National User Facilities in one research … provides customized analysis, the JGI also participates in publication of results. …