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And we’ve done some work with those and have a couple of publications out there on the chemistry. There’s so much … metabolism you know those numbers are still actually pretty high in terms of understanding from just sequence gazing … use some sort of screening center that can do this at high throughput. And so there are several of these throughout the …

… to be able to predict which one it was. And one of the challenges, at least right now with thioesterase on these … trans in order to cyclize at that small of a ring, which is highly unfavorable. DAN: Oh, I did not know that. That's … started that is a different subject is from microbes to medicine labs. So this is-- we've been working with both …

… of these compounds, which, in turn, translate into a high chemical diversity. So that’s just the type of … integrated metabolism, by Firn and Jones, because it’s highly tightly integrated in order to lead to the final … of natural product biosynthesis in bacteria ” The ActDES publication came out after we talked. It looks like a great …

… and microbiology just followed me all the way through my high school days in England.  DAN: What did your dad do in … and new ways to recover spinosyns. And so we had a high throughput screening platform where we’d look at 10,000, … help the Society grow. And so I’ve been the chair of the publications committee for the last, what is it now, five …

… many microbes. We still we work in plates, right? We’re a high throughput sequencing. We have high throughput sequencing … do the bioinformatics and to synthesize these results into publication? So there’s this really important because we …

… secondary metabolism, those things that we want to find are medicines. Medicine has always been the main driver for … and how we do it here and maybe give an example of a recent publication. ALISON TAKEMURA: Awesome. Yeah, let’s dive in, … but in subtle ways that affect fitness. And so, doing a high level kind of analysis, you just might not be able to …

… from one another. They are incredibly important to medicine, the environment, and human health. As the JGI acts …

… biology and a potential application of translation in medicine. So it’s a really great time to convene, you know, … this, called antibody drug conjugates, as a new type of medicine that will open up a new year for targeted anti … experience somewhere else, or you know, you’ve run into challenges that demonstrate why this is so important. BEN:  …

… mining and the directions it might take in the future. I highly recommend it. I’ll link to it in the show notes. … Usually, in a lot of cases, we still have to go through publications to get proteins, and their functions, and all … is not on the data side, but it’s still really the high throughput of getting these clusters activated. So most of …

… two sequenced genomes of a Streptomyces , or gram-positive high GC organism.  Dan: Yeah, not a lot of natural product … it’s really moved us into directions that, really, I think, challenges us as a laboratory. Initially, my group really … a lot of fun in, is really thinking about how one delivers medicines for tomorrow. And we typically think of medicines …

… first described by Stanley and Konopa in 1985, which highlights our skewed understanding of microbial metabolism … the metabolic potential of uncultivated lineages is of high value to establish models and hypotheses, experimental … … Research Interests … Former Lab Members … Selected Publications … For further details, please reach out to the …

… we’ll say methyl so we call them methylotrophs [ muh-thigh-luh-trophs ]. This is like, every square is a … up on previous Natural Prodcast episodes  here . Show Notes Publication: Suo Z et al. A Mesorhizobium japonicum quorum … 2023 Aug 31;14(4):e0101023. doi: 10.1128/mbio.01010-23. Publication: Cummings DA Jr. Methylotroph Quorum Sensing …