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… to regulate Earth's carbon balance, to exploring the genetic basis of how plants have naturally adapted to varied … climate and soil conditions around the globe to identify genes to improve our domesticated species.  The program supports the development of next-generation biofuels by studying perennial grasses and …

… that produces those. So it’s not a hard and fast rule, but, generally, animals do not have secondary metabolism that we … small molecules that they use to communicate – lots of terpenes, and little modified amino acids, and things that … before, you might not recognize that this weird, fatty acid synthase kind of system, like, maybe this bacteria just …

… bit more into fungi and learning the differences of all the genetic differences and then expanded on on that knowledge … JACLYN WINTER: So I actually– well, I mean, not having family in science, it was hard to see what are the different … And I think a lot of times, too, when we even look at publications, it’s always positive data, right? No one ever …

… And we’ve done some work with those and have a couple of publications out there on the chemistry. There’s so much … products is that we don’t know what all the biosynthetic gene clusters look like.  DAN: For sure.  MARCY: We have so … to look for right? And so, like, a type I polyketide synthase is very easy to search for because there are …

… the active site of an enzyme. So there is no promiscuity, generally speaking, in primary metabolism. Nevertheless, … the raw material– for example, in the cases of polyketide synthases, the fatty acid synthases should actually be the raw material, then trying …

… energy and ecosystem management. The program aims to generate high-quality genomic datasets, particularly for … single cell approaches. This includes linking strain-level genetic variation to ecological niche adaptations.  Single … and epigenomics. Expansion of sequence space:  The JGI generates reference genomes from diverse bacterial and …

… Program supports a wide range of projects, from single-gene synthesis to the synthesis of entire chromosomes, … the program enables the design and synthesis of complex genetic pathways and biosystems. It The program fosters … in advancing functional genomics, focusing on developing genetic systems that can address global energy and …

… technology to help access complicated natural product gene clusters, and we’re all really excited about that, and … structure – the enediyne compound that people know, as a family, it’s more than 7 decades. So, this family of … that we are working on into perspective in the field in general. So what has happened in the past two decades is …

… After I got my undergraduate degree, which was in general biology, I joined the Peace Corps. And when I was … thing is though, you might have the same backbone gene synthases, but having a different decoration enzyme actually … have on cluster sets that are sort of the same. You know, family clusters, like if you looked at the statins, you …

… complexity, and encode for a treasure trove full of novel genes ready to be tapped for downstream applications. … threats in environmental samples. This work combines third generation sequencing and machine learning to enable fast, … A complete publication list available at Google Scholar. Dutkiewicz, Z. …

… include exploration of the global diversity of alternative genetic codes (Science 2014), unearthing hundreds of … Science 2017, Nature Microbiology 2018), discovery of new genes with important biotechnological applications (e.g., … Camargo AP. et al. (2023) Identification of mobile genetic elements with geNomad. Nat Biotechnol . Epub. Neri …