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… DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s … and how we do it here and maybe give an example of a recent publication. ALISON TAKEMURA: Awesome. Yeah, let’s dive in, … ago. Non-ribosomal peptides, remember, are big, complicated enzyme systems that really just exist to pull an amino acid …

… The JGI has diverse capabilities in: DNA and RNA sequencing, Sample and library preparation, Biodesign and pathway engineering Mass spectrometry based metabolomics Below is a table of standard product offerings, including a description of … Q1  (median/75th percentile*) DNA Synthesis Constructs <5kb in size Single gene or multiple small genes assembled to …

… Data produced and released by the US Department of Energy (DOE) Joint Genome Institute (JGI) are subject to the following Data … Embargo : A period in which data is not publicly available in JGI systems or … PIs or co-PIs) who wish to include use-restricted data in publications, or who wish to redistribute data in any way …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … the “Non-Ribosomal Peptide Synthetases” or NRPSs. These are enzyme systems that grab amino acids and stick them together … Episode Transcript … you’d like to read more about this, I highly recommend his publication last year, “The Biosynthetic Diversity of the …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … Right. Yeah. DAN: Alright, so a subset of proteins are enzymes. Enzymes are proteins that do chemical reactions. … not actually on the structure of the protein that you’re engineering… Yeah, the complete system. So there’s more to …

… DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s … Usually, in a lot of cases, we still have to go through publications to get proteins, and their functions, and all … And then you search for – re-search for these biosynthetic enzymes that we think must be similar within the fosmid …

… right. Welcome back to Natural Prodcast. I did it. I’m keeping to my schedule. This should be coming out on the first … But on the other hand, we're also really interested in enzymes to do some of the reactions that chemists find … inspired molecules that you have, what assays are you testing them in? Because a lot of these compounds are really …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … might make this molecule and predicting what kind of enzymes might be involved, and then being able to make those … medicine” as a way of the future. We’re really good at engineering small molecules into microbes and making those …

… See below for examples of successful Letters of Intent to our Community … Linking lignin engineering to drought stress resilience: RNA-seq and metabolomic insights in lignin biosynthetic … Elucidating Sphagnum microbiome genetic interactions for improved … Adaptive strategies in a cosmopolitan and abundant soil bacterium: genetic …

… See below for a list of Frequently Asked Questions about our proposal … submission process. You can review successful letters of intent and submissions at the bottom of the page.  … Review the list of open calls ; click on the call link to see specific details including project types …

… Dan Udwary: You’re listening to the Department of Energy Joint Genome Institute’s … However – and this was a proposal on synthetic biology of engineering gene expression in bacteria – however, the … some of these enormous genes that encode these very large enzymes. And I was like, OK, wow, these are really cool. And …

… Research in the Woyke laboratory focuses on the utility of single-cell methods to access genetic material of … uncultivated Bacteria and Archaea has steadily been widening since 2005. This gap is also reflected in the strongly biased representation of sequenced genomes in the public domain, the bulk of which …