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… are shaping each part of the metabolic network in each specific organism. Really, what matters is the forces that … they don’t tend to be exposed to many dramatic changes, environmentally speaking. It’s hard to imagine that there … of natural product biosynthesis in bacteria ” The ActDES publication came out after we talked. It looks like a great …

… how unique they are, how they survive in this hypersaline environment, which can range from 8% to 28% salinity. We … was that it was one of the first genomes that had been done specifically in order to explore its secondary metabolism, … And I think a lot of times, too, when we even look at publications, it’s always positive data, right? No one ever …

… for and explore the chemistry of quorum sensing systems, specifically the acyl homoserine lactones.  If you listened … doing unless there’s enough of them around to affect their environment. So I think the classical example yeah, is … up on previous Natural Prodcast episodes  here . Show Notes Publication: Suo Z et al. A Mesorhizobium japonicum quorum …

Genome Institute is under the DOE’s mission of energy and environment. And so we know that lots of different types of … and how we do it here and maybe give an example of a recent publication. ALISON TAKEMURA: Awesome. Yeah, let’s dive in, … of a polyketide synthase. Each domain catalyzes some specific reaction. And so I would take a collection of …

So lots of reasons that I was attracted to work in that environment. Yeah, so that was here in San Diego. So yeah, … sequence into an antibiotic that kills bacteria through a specific mechanism. Or whatever that peptide might be doing. … you’d like to read more about this, I highly recommend his publication last year, “The Biosynthetic Diversity of the …

… issues, as needed Users are notified as projects reach specific milestones, either by automated emails or emails … access your data, share with collaborators, and coordinate publication with JGI scientists. Synthetic DNA constructs …

… since 2012, with a focus on addressing critical energy and environmental challenges. Through innovative research in … analyzing enzymes to support mission-driven research. Rapid Metabolic Engineering: Metabolic engineering traditionally … nodes. These families allow easy access to clade-specific orthology/paralogy relationships as well as …

… of Science user facility supported by the Biological and Environmental Research program, the Joint Genome Institute … research community in studies of complex biological and environmental systems. We optimize our service to the … Supported by the DOE Office of Science's Biological and Environmental Research program, the JGI unites the expertise …

… let’s see what caves have to offer because they’re unique environments. These are structures that are millions of … different approaches. Some of them have been actinomycete-specific approaches. And you can enrich for rare … to merge with the synthetic biology community, with the metabolic engineering community because the skill sets are …

… provides customized analysis, the JGI also participates in publication of results. … All proposals undergo technical … Following DOE approval, project managers negotiate project specifics with PIs (including JGI scientists as needed), and …