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… Microbes drive critical ecosystem functions and affect global nutrient cycling, however they do so under strong constraints exerted by viruses. Research in the viral genomics … While an ever-increasing number of phage and virus genomes have been … our understanding of the impacts of these viruses on microbiome processes is still limited. One key challenge is …

… ALISON TAKEMURA: I know that it’s looking in the genome for genetic elements of interest, you know, something like … and how we do it here and maybe give an example of a recent publication. ALISON TAKEMURA: Awesome. Yeah, let’s dive in, … of Earth’s Microbiomes. And what this is, is a data set of bacterial and archaeal genomes that were created – these are …

… and BiG-SLiCE, and now the BiG-FAM database of biosynthetic gene cluster families. And he tells us about forthcoming … Integrated Microbial Genomics at JGI, a large data set of bacterial genomes. And so yeah, we use antiSMASH to identify … key aims that’s related to what I was just talking about is elucidating functions of the gene clusters in their …

… See below for examples of successful Letters of Intent to our Community Science Program Large-Scale Call, as well as successful submissions to our CSP New Investigator, CSP Functional Genomics, and Facilities Integrating Collaborations for User Science calls. These …

… The JGI’s Microbial Program focuses on using cutting-edge sequencing, annotation and analysis techniques to explore the vast … energy and ecosystem management. The program aims to generate high-quality genomic datasets, particularly for … laboratory isolation and genome sequencing of underexplored bacterial and archaeal lineages that are important for …

… and he has a project with the JGI to synthesize the genes for and explore the chemistry of quorum sensing … cluster with me because it turns out that oftentimes in bacterial genomes if you have a quorum sensing system or the … of molecules can be thought of as signals or have other functions depending on their concentration and their …

… bioprospecting vs biopiracy, early stage drug discovery in general, and a possible data-driven future for plant natural … a check-up on me. And I wonder how that intersects with bacterial bioprospecting that is often done, where we’re … I think on COVID that we’re getting ready to submit for publication and have found some interesting hits for that as …

…   The U.S. Department of Energy (DOE) Joint Genome Institute (JGI) is a national user facility located at … as the DOE Systems Biology Knowledgebase and the National Microbiome Data Collective.    … The U.S. Department of Energy (DOE) Joint Genome Institute (JGI) is a high-throughput AI-centric …

… Synthesis Program supports a wide range of projects, from single-gene synthesis to the synthesis of entire chromosomes, … the program enables the design and synthesis of complex genetic pathways and biosystems. It The program fosters … in advancing functional genomics, focusing on developing genetic systems that can address global energy and …

… Research in the Woyke laboratory focuses on the utility of single-cell methods to access genetic material of uncultivated taxa of interest. One such … that are from candidate phyla, major branches in the phylogenetic tree without cultivated representatives. The “Great …

… right. Welcome back to Natural Prodcast. I did it. I’m keeping to my schedule. This should be coming out on the first … about several different pieces of her work, including bacterial quorum sensing and its effects on regulation of … oftentimes will bind to receptors within biosynthetic gene clusters. Specifically, these are Tet repressors that …

… organs that solely house– whose sole function is to house bacterial associates. And so the one that the Hawaiian … And we’ve done some work with those and have a couple of publications out there on the chemistry. There’s so much … products is that we don’t know what all the biosynthetic gene clusters look like.  DAN: For sure.  MARCY: We have so …