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… DAN: You’re listening to the US Department of Energy Joint … on this: Most of the machinery in any living organism are proteins, which are made up of chains of amino acids. … A second area that I’m really interested in is how to use design principles to make new compounds. And that’s related …

… with their target. And so, for example, you could think of designing one of those that can trick an enzyme into … up now with JGI is we identified using some different computational methods a bunch of different syntheses that … more structural diversity — so that one uses acyl carrier proteins as co-substrate. So the other ones they use CoA …

… With collaborative user projects, the JGI’s Plant Program delves into the … global challenges by exploring plants’ role in capturing carbon, detoxifying soils, interacting with other organisms, … including deep learning algorithms for gene annotation and protein folding models, to improve the accuracy of …

… DAN UDWARY: You’re listening to the Department of Energy … be the amino acid that is relevant for the synthesis of proteins, and will more often end up in the active site of … a chemical history. So it is not an easy one, obviously, to design an experiment rather than just going for evidence on …

… is being this engineer that’s constantly refining its designs. But sometimes if you’re looking at it from a zoomed … Usually, in a lot of cases, we still have to go through publications to get proteins, and their functions, and all that stuff. And … Episode Transcript …

… Biology is currently experiencing a revolution brought on by rapid developments in genomics and other omics technologies.  The exponential growth of DNA sequencing data, coupled with recent computational technology advances in management, processing … The research efforts of the group have concentrated in demonstrating …

… The Metagenome Program uses advanced sequencing technologies to decode the genomes of … and their metabolic functional potential. This research enables us to better understand how microbial communities … and their evolution. The Program focuses on developing computational tools and visualization resources that support …

… The Fungal & Algal Program explores the vast diversity of fungi and algae to … that enable fungi and algae to play a vital role in carbon cycling, biodegradation and biogeochemistry. This … The Fungal & Algal Program harnesses cutting-edge sequencing … play a critical role in ecological processes such as carbon cycling, biodegradation and biogeochemistry. The …

… Dan Udwary: You’re listening to the Department of Energy … the project was a mixture, initially, of experimental and computational work. And that it involves some of these crazy … with sequence similarity, either we just looked at which protein domains are in a gene cluster or we did sequence …

… DAN UDWARY: You’re listening to the Department of Energy … itself medicine, but the coding within the DNA codes for proteins that do the chemistry that put molecules together … and how we do it here and maybe give an example of a recent publication. ALISON TAKEMURA: Awesome. Yeah, let’s dive in, …

… DAN: All right. Welcome back to Natural Prodcast. I did it. … bind similar ligands. And so one of-- DAN: OK. The similar proteins are going to bind similar molecules. Yeah, OK. … actually produced. And once we figure that out, we have designed GFP based plasmids where we can actually then put …