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… first episode you’re checking out, you probably want to go back and listen to the first two parts ( part 1 is here and … as anything in this field, and written pretty close to the level of technical detail that I think we’re doing here. If … dynamics of the biochemistry that’s happening on a protein level. We also don’t quite always know how these evolve. We …

… cluster per week. And that really got me excited. And I stopped thinking about doing a postdoc and went to industry … systems. But it allows us to assay on a single cell level against cell lines and against primary cells isolated … a good catalog of what’s out there so that we can do more comparative analysis and maybe– I don’t know– start to put …

… … DAN: Hello, everyone, and Welcome back for Episode 14 of Natural Prodcast . There’s been a lot … directed genomics approaches, DAPseq and the stabilized isotope probing work that we’re doing, single cell work we’re … vaccines and controls that are in place will help us get on top of this pandemic. And we’ll be able to manage our lives …

… through Natural Prodcast, especially those who have unique backgrounds or interesting stories to tell. Academic … And we’re asking students and undergraduate and high school level classrooms to (A) become engaged with STEM and learn … sequencing do we need to do? MARC: Well, we should never stop sequencing otherwise I’d be unemployed.  DAN: Likewise. …

… episode. These are episodes where Alison and I talk about a topic or kind of a subdiscipline in the natural products or … bacteria, because it is so easy to sequence their genomes comparatively to especially plants. So yeah, so from there, … you can basically usually predict, within a certain level of certainty, exactly what peptide is being produced …

… … DAN: All right. Welcome back to Natural Prodcast. I did it. I’m keeping to my … we're primarily doing this by mass spec seeing different levels go up and down. We're pretty early on in that … Natural Prodcast episodes  here .   Show Notes Some of the topics we cover in this episode: Synthetic Natural Product …

… and scientists of secondary metabolism.  DAN: Welcome back to Natural Prodcast! This is episode 4! From here on … produced by Fusarium species that was produced to very high levels in South Africa, including Lesotho where I done my … is that? It looks like it’s encoding an enzyme, there’s no stop. So finding out – expressing the quiet clusters and then …

… work like ActDES, which is a curated database of actinobacteria for evolutionary studies, and hopefully we can … So let’s think about synthesis of an amino acid, like tryptophan. You are not allowing any chemical diversification … the beginning of the pathway, you need to end up with tryptophan, which will be the amino acid that is relevant for …

… … The JGI uniquely offers the first quantitative Stable Isotope Probing (SIP) Metagenomics pipeline that utilizes … to accurately measure environmental microbiome activity levels.This functional assay lets us move beyond cataloging … imaging with various microscopy techniques … Stable isotope probing metagenomics: … Single cell: … For further …

… with his work. Brad: Yeah, for sure. So we’re going back to the mid-late ’80s. And at that time, you know, it’s … Institute interested in a marine obligate actinomycete bacterium called Salinospora . This new genus was discovered … out, you know, high CO2. Turns out you know, when nitrogen levels change in the ocean, you begin to see those genes be …