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… and this will be episode 11. This continues our little sprint on genome mining. In the last episode , Alison and I … been dead center and a lot of the really important recent events in data analysis and secondary metabolism over the …

… our HERE (TK) , used successfully by investigators in the past.  These protocols are not endorsed by and have not been … Phytozome (citation: https://doi.org/10.1093/nar/gkr944 ) The following tools are available for functional … Policy & Support page.  … Please review our Webinars and Events pages for details.  … Who is my project manager? … …

… … DAN: Hello, everyone, and Welcome back for Episode 14 of Natural Prodcast . There’s been a lot going on, so I … on to talk about JGI’s vision for secondary metabolism, his past in industry in developing natural products for … did some sigma factor work and anti-sigma factors. in my past life.  DAN: Yeah, I didn’t really appreciate that …

… that if you looked at the grant applications for the last 40 years for studying biosynthetic pathways, all of them … be difficult to write a grant on right now like another P450 or glycosyltransferase. You probably would have a hard … https://sim.confex.com/sim/np2023/meetingapp.cgi/Paper/46926 Jen Wurm:  …

… so my collaborator and I have this idea that they work like pastry bags almost and so they are essentially squeezed out … a long time whenever you did a genome sequence, in about 40% of the genome the genes were completely unidentifiable. …

… these missions, and to expand upon highly successful past collaborations, the DOE JGI, NERSC and KBase issued a …

… now there are six ADCs that have been FDA approved over the past two decades, and, remarkably, of the six, two of them … of microbial origin is around 30,000 from fungal, and a 40,000 from bacteria. Okay? And among the 40,000 from … So, you may know the so-called Nagoya protocol, which prevents taking bio-resources from the native countries. So …

… in Yu et al, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2004, 1253–1262, 70:3 ALISON TAKEMURA: And so did you succeed … So within ABC, we have something in the neighborhood of 400,000, last I checked, biosynthetic gene clusters. And … RiPPs. That sort of holds up with what we have seen in the past with people that have done metagenomic studies on, say, …

… cliques, it has also become possible to identify speciation events within existing species. Within the JGI’s production …

… marine natural products. And was at the university for over 40 years. There were four of us as kids in the family. I was …

… which I haven’t seen in natural products a whole lot in the past. This sort of idea of, “there’s a lot of data out … is to graze across all of the published literature for the past hundred years and identify every article which … many there are to find. Conservatively, we estimate perhaps 40,000. The best we can do is take sections of the …