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… never forced it on me, but we always had these scientific news magazines lying around at home. And I would just pick … takes about 10 years. Costs are in the range of $100 to $120 million to do that.  DAN: OK. So about the same amount … looking at emails and I just saw this pop up. And saw a C&E News job little box and I thought, wow, this would be …

… in Yu et al, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2004, 1253–1262, 70:3 ALISON TAKEMURA: And so did you succeed … this is Challis et al, Chemistry and Biology, 2000, 211-224, 7:3 And so, you can then make predictions about NRPS’s … Microbiomes” paper is here . Read the associated JGI news release here . Software we discussed, used for genome …

… from metagenomes. mSystems 9:e00888-24. https://doi.org/10.1128/msystems.00888-24 Coclet, C., Sorensen, P.O., Karaoz, U. … Neri U., Wolf, Y., Roux S., Camargo A.P., et al. (2022) Expansion of the global RNA virome reveals diverse … of hypermutation in the global microbiome. Nat Commun 12, 3076. https://doi.org/10.1038/s41467-021-23402-7 Roux, …

… access to the whole sigma catalog of precursors in their 12C form. You can feed those and look for incorporation in … would grow up our bacteria on 13C methane or methanol, feed 12C methionine, and we were able to pull out the quorum … source and the other with 13C carbon source plus your 12C precursor. You look for a shift of four. Boom. It works …

… 10 to the negative 9th. Picomolar, 10 to the negative 12th. DAN: Yeah. So very-- BETSY PARKINSON: Very, very-- … the issues is in order to make the tetrapeptide, that's a 12 membered ring. And there's extreme ring strain in 12 membered rings. You also have to change the amide …

… discovered this and it got developed in somewhere around 2004, I guess, something like that, and now, 2021, it doesn’t …