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… secondary metabolite peptides. And there are two ways that nature does this. The more well-known secondary metabolism … can use peptides for! That’s what his collaboration with JGI is all about, and we talk about it a bit here. I have … But, say, the last time I checked, it was on the order of 10,000 species. And whenever you’re talking about a new …

… we discussed in the primer podcasts ( part 1 here , part 2 here , and part 3 here ), which you should be able to find … first started out the natural product community was almost 100% bacterial. Only people working in mycotoxins worked … actually, everything is funding, right, isn’t it? I thank JGI for sequencing a lot of fungi. But the thing with them – …

… things I want to make sure that we talk about. You have a JGI project going with us that we want to talk a little bit … seems hard to believe in retrospect. BILL FENICAL: Well, in 2021, absolutely hard to believe. But when you go way back, … convince those people of that fact, however, a long time, 10 years! ALISON TAKEMURA: Wow. It’s all happened so fast. I …

Europe. So if there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And … in the early 2000s? Late 2000s? NADINE ZIEMERT: No, yeah, 2010. ALISON TAKEMURA: 2010, OK. You’re a young faculty. …

… for the US Department of Energy Joint Genome Institute, or JGI. JGI is a DOE Office of Science User Facility located at … I have been in – working in secondary metabolism for almost 20 years now. Which when I did the math, that was a surprise … how funny, you know, the human endeavor of understanding nature is: we want to categorize things into these arbitrary …

… niche in chemical enzymology. So, we talked about her JGI DNA synthesis project to explore the chemical … also twofold but for different reasons to learn about how nature builds molecules because nature does this with such … I always use it as the first word in the title of my talk, 100% fair for you to make that association. DAN UDWARY: So I …

… — top-quality genomic data, open to all researchers. … The JGI Genome Portal provides unified access to all JGI genomic databases and analytical tools for all JGI sequencing projects. In 2021, the JGI launched the Data Portal to eventually replace …

… understand the chemical diversity and chemical utility that nature has to offer us. I found this conversation really … let me know! I’m dying to hear from you. Toss an email to  jgi[email protected] , or leave us a review on Apple Podcasts … accurate. And so we told people that if they would curate 1000 entries, that that would earn them authorship of the …

… with my co-host Alison Takemura, who’s moved on from JGI to do real journalism, and we wish her all the best. … We don’t want to get a proposal that’s just asking for 20 microbial genomes. That is not a good fit for our annual … proposals as well. I’ve been at the JGI for 20 years, and 10 of those years, I’ve been a project manager. MENAKA …

And I set that up. And we finally got that to work 10 years later. But in the meantime there, we had people … all sorts of different colors. I mean, where else in nature– and they’re not fungal. Where else nature can you go … at Scripps, I guess, 22 years ago. And it’s over 130 steps to make everninomicin. DAN UDWARY: Yeah, one of …

… to the second episode of the Natural Prodcast. This is part 2 of our “primer” episode, so if you ended up here somehow … But um, yeah, so secondary metabolism is throughout nature, except maybe for animals and humans, not as much. … have that goal. That’s not as much our goal here at the JGI – we are not a medicinally focused organization. And so, …

… the convention went– since the protocol went into force in 2014. There’s now a website that has a lot of resources that … these studies are lacking that. And so there’s no way to be 100% sure that the chemistry that they’re even reporting on … plants and bringing them back is not your jam, the good news is there’s this amazing resource that can be provided …