Search

… very excited today. Usually when we do these interviews, most of the people that I think we’ve talked to so far I … editor. And yeah, it just kind of came together in the most delightful and unexpected way. So I had to leave with … I was on crutches and because I couldn’t always wear my prosthetic leg. I had my leg amputated when I was three and …

… worked together on Aflatoxin biosynthesis while he was a postdoc in Craig Townsend’s lab at Johns Hopkins, where I was … the RiPPs, which stands for “Ribosomally synthesized and Post-translationally modified Peptides.” You’ll have to use … but there you go. A tiny bit of background on this: Most of the machinery in any living organism are proteins, …

… structurally resolved in the 1980s, they were known as the most toxic molecules, and that human beings know, today, for … enediyne compounds by coupling it with antibodies.  DAN (post edit): Hey, Dan here with a quick interjection. Ben … we can enrich the chemical space of natural products in almost a hundred-fold. That is going to change the world! And …

… having listened to the first part, you might be a little lost, and I’d suggest you go back and check the first episode … are still in – not an early stage. I think we can identify most secondary metabolism pathways now, but there’s still almost certainly unusual things that we don’t recognize, …

…  Learn about meetings the JGI is hosting:   … about upcoming user-focused webinars and workshops we're hosting. …

… talk a lot about some of the technical challenges to that, most of which seem to be history.   I should mention that … work was with a fungal pathogen called Cochliobulis heterostrophis . This is a very well known fungus because it … as you know, Daniel, I started working with aflatoxin, my postdoc, you know, these very potent, nasty natural products. …

… sequencing—to JGI. Users are responsible for covering the costs of the experiment, sample collection, and shipping; JGI … like expression constructs or sgRNA libraries to the user. Most users of the Molecular Foundry work side-by-side with … for their own living, local transportation, and travel costs. The cost of standard incidentals related to the user …

… of background. My name is Dan Udwary. I – as well as my co-host, Alison Takemura, whose voice you’ll hear in a minute – … basically all living things. When your crazy Aunt is posting on Facebook about cinnamon or turmeric curing every … natural products, even though the science in that Facebook post is probably more than a little fuzzy. The natural …

… in studying natural products? NADINE ZIEMERT: Like almost coincidence, I think. ALISON TAKEMURA: Oh! NADINE … the lab, I love the topic, and I think what I like the most is just the interdisciplinarity of it. So it wasn’t only … in San Diego] together. And I worked for Brad Moore as a postdoc and you were with Paul Jensen . NADINE ZIEMERT: And …

… would be Katherine. Dan Udwary: Right. Kate Duncan: But most people that know me call me Kate. Dan Udwary: Great. So … much the chemistry of natural products from invertebrates, mostly. Dan Udwary: Structure elucidation, yeah. Kate Duncan: … the biology and the chemistry. And then, yeah, I did a postdoc with Paul Jensen, Scripps Oceanography. And as I say …

… line of communication to the scientific community. Host Dan Udwary talks to luminaries in the field about …

… we’re going to finish up by talking about the modern, post-golden age history of natural products discovery, and … the information age and the ebook version is available at most online sellers. I think it’s as accessible as anything … Primer! — DAN: So, you know, in the in the 50s 60s 70s, most of the exploration of this is done by what’s called …