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… on the utility of single-cell methods to access genetic material of uncultivated taxa of interest. One such effort … in 1985, which highlights our skewed understanding of microbial metabolism towards a minority of cultivated … Phylogenetic diversity estimates show that the gap between cultivated and uncultivated …

… marine natural products, as such, but things like “Silent Spring” by Rachel Carson, and things about understanding the … And sometimes, in terms of biological activities– like antimicrobial or something– sometimes a little difference is … and culture things under lab settings, we’re getting a snapshot in an artificial environment. And if we really want to …

… from a professional stance I’m an associate professor of Dermatology in Human Health at Emory University based in … scientists to think about, because if you look at the 36 hotspots, or terrestrial biodiversity hotspots that we have … that we found, indeed, that both formulations had some antimicrobial properties. But the one that was used in …

… people were trying to locate and sequence and get the information on biosynthetic gene clusters. And I’ll explain all … the genomics. So– ALISON TAKEMURA: I’m just enjoying the ride right now. Go ahead. DAN UDWARY: So you would start by … of the IMG data portal , which is a larger portal for microbial genomics. IMG stands for Integrated Microbial …

… Minimal Draft Lower coverage short-read whole genome shotgun sequencing Assembly, annotation ( Mycocosm ) 256/404 … acids, nucleosides, etc) metabolites using normal phase chromatography coupled to tandem mass spectrometry Metabolite … physical separation of a biologically relevant unit from a microbial community, such as a microcolony, microbial …

… to predict or just understand better the language of microbial cell-cell communication. And he told us about his … as tool building. So I worked with a really great guy named Matt Bogyo in grad school synthesizing activity based probes … compounds like methanol and methane. And I really dove into microbial physiology and microbial genetics, and really away …

… I can point people to when it comes to getting out information about both SMC, and Jackie, so please do hop over … correct, yeah. So they’re actually these– it’s called dust hotspots on the lake. So the lake is [INAUDIBLE] with … are familiar with JGI’s IMG data portal , the Integrated Microbial Genomics, there was a subsection of that called …

… applied to samples collected from acidic iron-oxide microbial mats in Yellowstone National Park over time, researchers … role in the development of life on Earth; the iron-oxide microbial mats at Yellowstone offer researchers an analog … Computing System, operated and supported by MSU’s Information Technology Center. …

… Canada. This is the last of the podcasts we recorded in my hotel room at SIMB, or the Society for Industrial … better connect those two things, because I think that’s ultimately what needs to happen if we’re really going to … to try and create an open source database of all known microbial natural products. So if you think about natural …

… kinds of organisms, from plants and fungi to microbes and viruses. Listen in to explore the data that illuminates …