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… This is part 2 of our “primer” episode, so if you ended up here somehow without having listened to the first part, you … we can identify most secondary metabolism pathways now, but there’s still almost certainly unusual things that we don’t … derivatives of natural products.  ALISON: Like such a large diversity can have similar effects, I think is also …

… archaea, and micro-eukaryoes, along with their associated viruses and mobile genetic elements. Beyond exploring and … evolutionary time scales.The Metagenome Program combines large-scale, time-series metagenomic data with detailed … viral ‘dark matter’:   Viruses are abundant in the biosphere and influence microbial dynamics, evolution, and …

… as well as the development of novel methods to enable large-scale comparative analysis, mining and visualization … Nature Biotechnol.  39(1):105-114. Schulz F, et al. (2020) Giant virus diversity and host interactions through global … Nature 578(7795):432-436 Sberro H, et al. (2019) Large-Scale Analyses of Human Microbiomes Reveal Thousands …

… from Vanderbilt University’s Chemistry Department, where he is the PI of the Laboratory for Biosynthetic … or through the JGI website at jgi.doe.gov . There’s a lot more to talk about there, and I’ll be getting … active in a heterologous host. So what you really need is a large tool kit of pieces in order to put them together to …

… bioeconomy applications. The program provides high-quality, large-scale genomic data to advance microbial research that … associated with microeukaryotes. The program also studies giant viruses. Key research areas include terrestrial … particularly for uncultivated microorganisms, by sequencing large populations of bacteria and archaea in their natural …

… know me call me Kate. Dan Udwary: Great. So we’ve got Kate here today, and we wanted to talk to her about a whole list … idea of taking all the different natural products data that there is and putting things, coalescing them, so that we can … on so many levels. So first, I mean, all bacteria are everywhere. But the fact that actinomycetes form spores and …

… of the term “secondary metabolism.” And so we talk a lot here about the terminology we use and where it falls short, … the terms we should be using for what we do are, and why there and why it’s important to make those distinctions. … it is now like a very toxic compound that will actually go everywhere and cause a lot of trouble. DAN UDWARY: Oh, yeah. …

… especially when you’re working in natural products right. There’s many different avenues toward chemistry. But that’s … assays is what those would be. The work that we do at larger scale in order to look at the chemistry a little bit … inhibit other bacteria using secondary metabolites Here’s a great recent example of some of her work on …

… Sciences. She’s an ethnobotanist and the herbarium curator there, with a broad range of experimental work on plants for … over into the Arabian Peninsula, and then into Europe, and everywhere now. But was there any reward to the people that …

… allows us to provide diverse scientific communities with large amounts of standardized high-quality data and … Looking for BBTools? Find it here.  …

… and Welcome back for Episode 14 of Natural Prodcast . There’s been a lot going on, so I took a little break, but … into that?  NIGEL MOUNCEY: Secondary metabolism fits everywhere! [LAUGHTER]  DAN: I think it does.  NIGEL … A Vision for Integrative and Collaborative Genome Science,” here .  And join us August 30 – September 1 for JGI’s Annual …

… work, in genome mining, we have an awful lot of crossover, where us genome miners get really jazzed about finding … it to be useful? Not in a process chemistry route because there, you just need to build one molecule. But what I would … students to work in my group, it looked like he had like a giant thing of like candy corn on his bench. And I was like, …